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Machine translation
1. (WO1980000216) INHIBITION BY PEPTIDES OF TOLERANCE TO AND DEPENDENCE ON MORPHINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1980/000216    International Application No.:    PCT/US1979/000492
Publication Date: 21.02.1980 International Filing Date: 09.07.1979
IPC:
A61K 38/04 (2006.01), C07K 5/06 (2006.01), C07K 5/062 (2006.01), C07K 5/078 (2006.01), C07K 5/097 (2006.01), C07K 5/103 (2006.01), C07K 5/12 (2006.01), A61K 38/00 (2006.01)
Applicants:
Inventors:
Priority Data:
923187 10.07.1978 US
Title (EN) INHIBITION BY PEPTIDES OF TOLERANCE TO AND DEPENDENCE ON MORPHINE
(FR) INHIBITION PAR DES PEPTIDES DE LA TOLERANCE ET DE LA DEPENDANCE PHYSIQUES A LA MORPHINE
Abstract: front page image
(EN)Certain peptides administered during chronic morphine treatment were found to be effective in preventing development of tolerance and physical dependence. Particularly effective are prolyl-leucyl-glycinamide, cyclo(leucylglycine), and the protected peptide N-carbobenzoxy-prolyl-D-leucine, which, injected daily into mice receiving chronic morphine treatment, prevented the development of physical dependency as measured by changes in body temperature and body weight, either during abrupt or naloxone induced withdrawal. But injection of peptide only on the last day of morphine treatment did not alter the overt signs of withdrawal. Daily injection of peptide was also effective in blocking the development of tolerance to analgesic and hypothermic effects of subsequent challenge doses of morphine. The peptide treatment did not alter the acute effects of morphine on either analgesia or body temperature. No effects on memory were noted, as evaluated in a one-trial passive avoidance task.
(FR)Certains peptides administres pendant un traitement chronique a la morphine se sont reveles etre efficaces dans la prevention du developpement de la tolerance et de la dependance physiques. Les peptides particulierement efficaces sont le prolyle-leucyle-glycinamide, le cyclo (leucyleglycle), et le peptide protege- N-carbobenzoxy-prolyle-D-leucyle, qui, injectes quotidiennement dans des souris recevant un traitement chronique de morphine, ont empeche le developpement de la dependance physique, ce qui a ete mesuree par des changements de la temperature et du poids du corps, soit lors d"un arret brusque ou sous naloxone. Toutefois l"injection d"un peptide le dernier jour seulement du traitement a morphine n"a pas altere les signes manifestes de l"arret. L"injection quotidienne d"un peptide s"est revelee egalement efficace pour bloquer le developpement de la tolerance aux effets analgesiques et hypothermiques de doses ulterieures provocatrices de morphine. Le traitement de peptides n"a pas altere les effets aigus de la morphine sur l"analgesie ou la temperature du corps. Aucun effet sur la memoire n"a ete remarque comme cela a pu etre evalue dans un exercice d"epreuve a annulation passive.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)