Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1980000025) DERIVATIVES OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID,PREPARATIONS AND USE THEREOF AND TETRAHYDROPYRAN-2,3,5-TRIONE INTERMEDIATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1980/000025 International Application No.: PCT/US1979/000376
Publication Date: 10.01.1980 International Filing Date: 29.05.1979
IPC:
C07C 33/30 (2006.01) ,C07C 45/31 (2006.01) ,C07D 307/68 (2006.01) ,C07D 309/36 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
33
Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
28
Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
30
monocyclic
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
27
by oxidation
31
with compounds containing mercury atoms, which may be regenerated in situ, e.g. by oxygen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
56
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
68
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
34
having three or more double bonds between ring members or between ring members and non-ring members
36
with oxygen atoms directly attached to ring carbon atoms
Applicants:
Inventors:
Priority Data:
91279805.06.1978US
Title (EN) DERIVATIVES OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID,PREPARATIONS AND USE THEREOF AND TETRAHYDROPYRAN-2,3,5-TRIONE INTERMEDIATES
(FR) DERIVES D"ACIDE 4,5-DIHYDRO-4-OXOFURANE-2-CARBOXYLIQUE, LEUR PREPARATION ET LEUR UTILISATION, ET PRODUITS INTERMEDIAIRES DE TETRAHYDROPYRANE-2,3,5-TRIONE
Abstract:
(EN) Compounds of formula I (FORMULA) in which R1 and R2 each is lower alkyl, cyclo (lower) alkyl, lower alkoxy (lower) alkylene, phenyl or phenyl mono- or disubstituted with lower alkyl, lower alkoxy, halo, nitro or trifluoromethyl; or R1 and R2 together form a -(CH2)m-X-(CH2)n- chain wherein m and n each is an integer from one to four and X is methylene, oxa or thia; or R1 and R2 together with the carbon atom to which they are joined form a spiro(1,2,3,4-tetrahydro napthalene)-1 or spiro(indan)-1 radical; R3 is hydrogen or lower alkyl; and R4 is hydrogen, lower alkyl, cyclo (lower) alkyl, phenyl (lower) alkylene, amino (lower) alkylene, lower alkyl-amino (lower) alkylene, di (lower alkyl) amino (lower) alkylene or 3-pyridinyl (lower) alkylene, or a therapeutically acceptable addition salt thereof are disclosed which possess hypolipidemic activity, and can be used in pharmaceutical compositions. The compounds of formula I may be prepared by cyclising a corresponding compound of formula X (FORMULA) and if desired esterifying. Tetrahydropyran-2,3,5-trione intermediates are also disclosed.
(FR) Composes de formule I (FORMULE) dans laquelle R1 et R2 sont chacun un alkyle inferieur, un cycloalkyle (inferieur), un alkoxy inferieur alkylene (inferieur), un phenyle ou phenyle mono ou bisubstitue avec un alkyle inferieur, un alkoxy inferieur, un nitro ou trifluoromethyle; ou R1 et R2 forment ensemble une chaine - (CH2) m - X - (CH2) n - dans laquelle m et n sont chacun un nombre entier compris entre un et quatre et X est un methylene, oxa ou thia; ou R1 et R2 forment ensemble avec l"atome de carbone auquel ils sont rattaches un radical spiro (1,2,3,4-tetrahydronaphtalene)-1 ou un radical spiro(indan)-; R3 est l"hydrogene ou un alkyle inferieur et R4 est l"hydrogene, un alkyle inferieur, un cycloalkyle (inferieur), un phenyle, un alkylene (inferieur), un alkylene amino inferieur, un alkyle amino alkylene (inferieur), un diamino (alkyle inferieur) alkylene (inferieur) ou 3-pyridinyle alkylene (inferieur), ou un sel d"addition therapeutiquement acceptable, presentent une activite hypolipidique et peuvent etre utilises dans des compositions pharmaceutiques. Les composes de formule I peuvent etre prepares par cyclisation d"un compose correspondant de formule X (FORMULE) et, si desire, par esterification. Des substances intermediaires de tetrahydropyrane-2,3,5-trione sont egalement decrites.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)