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Machine translation
1. (WO1979001068) 2"-SUBSTITUTED ARABINOFURANOSYL NUCLEOSIDES AND NUCLEOTIDES INTERMEDIATES,PREPARATION AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1979/001068    International Application No.:    PCT/US1979/000325
Publication Date: 13.12.1979 International Filing Date: 14.05.1979
IPC:
C07H 19/06 (2006.01), C07H 19/16 (2006.01), C07H 9/04 (2006.01)
Applicants:
Inventors:
Priority Data:
905529 12.05.1978 US
Title (EN) 2"-SUBSTITUTED ARABINOFURANOSYL NUCLEOSIDES AND NUCLEOTIDES INTERMEDIATES,PREPARATION AND USE THEREOF
(FR) PRODUITS INTERMEDIAIRES DE NUCLEOSIDES ET NUCLEOTIDES DE 2"-ARABINOFURANOSYL SUBSTITUE LEUR PREPARATION ET UTILISATION
Abstract: front page image
(EN)Novel arabinofuranosyl nucleosides and nucleotides having 2"-azido, 2"-amino, or 2"-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1, 3-oxazine base with an acylated 2-azido-2-deoxyarabinofuranosyl halide, followed by deblocking and catalytic hydrogenation, where appropriate, to convert the 2"-azido group to a 2"-amino group and, if desired, alkylation or the like to convert the 2"-amino group to a 2"-hydrocarbylamino group.
(FR)Des nucleosides et des nucleotides d"arabinofuranosyle nouveaux avec des substituants 2"-azido, 2"-amino ou 2"-hydrocarbylamino ayant des proprietes antitumorales, antivirales et antimicrobiennes sont prepares par condensation d"une base de pyrimidine, purine ou 1,3-oxazine avec un halogenure de 2-azido-2-deoxyarabino-furanosyle acyle suivi par un deblocage et une hydrogenation catalytique, si necessaire, pour convertir le groupe 2"-azido en un groupe 2"-amino et, si l"on veut, par une alkylation ou un autre procede semblable pour convertir le groupe 2"-amino en un groupe 2"-hydrocarbylamino.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)