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Machine translation
1. (WO1979001037) 1-HYDROXYALKANAMINE PYRANO(3,4-B)INDOLE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1979/001037    International Application No.:    PCT/US1979/000256
Publication Date: 29.11.1979 International Filing Date: 19.04.1979
IPC:
C07D 491/04 (2006.01), C07D 495/04 (2006.01)
Applicants:
Inventors:
Priority Data:
904081 08.05.1978 US
Title (EN) 1-HYDROXYALKANAMINE PYRANO(3,4-B)INDOLE DERIVATIVES
(FR) DERIVES D"INDOLS-1-HYDROXYALKANAMINE PYRANO (3,4-B)
Abstract: front page image
(EN)New compounds of formula I (FORMULA) in which R1 is lower alkyl; R2 is hydrogen or lower alkyl; R3 and R4 each independently is hydrogen, lower alkyl halo, nitro, trifluoromethyl or lower alkoxy; R5 and R6 each independently is hydrogen or lower alkyl or R5 and R6 together with the nitrogen atom form a pyrrol-1-yl, piperidino or morpholino ring; R7 is hydrogen or lower alkyl; Alk1 and Alk2 each independently is a straight or branched chain lower alkylene having one to six carbon atoms; and X is oxa or thia, and therapeutically acceptable acid addition salts thereof. The above compounds are diuretic agents, which also possess anti-hypertensive activity. They may be used alone or with other diuretic agents. Pharmaceutical compositions containing the compounds and processes for preparing the compounds are also described.
(FR)Nouveaux composes de formule I (FORMULE) dans laquelle R1 est un alkyl inferieur; R2 est l"hydrogene ou un alkyle inferieur; R3 et R4 chacun independamment est un hydrogene, un alkyle inferieur, un halo, un nitro, un trifluoromethyle ou un alkoxy inferieur; R5 et R6, chacun independamment, est un hydrogene ou un alkyle inferieur ou R5 et R6 ensemble avec l"atome d"azote forment un cycle pyrrol-1-yl, piperidino ou morpholino; R7 est un hydrogene ou un alkyle inferieur; Alk1 et Alk2, chacun independamment, est une chaine alkylene inferieure lineaire ou ramifiee ayant de un a six atomes de carbone; et X est un oxa ou un thia, et leurs sels d"addition acide therapeutiquement acceptables. Les composes cites ci-dessus sont des agents diuretiques, qui ont aussi une activite anti-hypertensive Ils peuvent etre utilises seuls ou avec d"autres agents diuretiques. Des compositions pharmaceutiques contenant les composes et les procedes de preparation des composes font aussi partie de la description de l"invention.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)