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Machine translation
1. (WO1979000941) PYRIDAZINE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1979/000941    International Application No.:    PCT/JP1979/000094
Publication Date: 15.11.1979 International Filing Date: 13.04.1979
IPC:
C07D 401/14 (2006.01), C07D 403/04 (2006.01), C07D 405/12 (2006.01), C07D 405/14 (2006.01), C07D 409/14 (2006.01)
Applicants:
Inventors:
Priority Data:
78/46354 18.04.1978 JP
Title (EN) PYRIDAZINE COMPOUNDS
(FR) COMPOSES DE PYRIDAZINE
Abstract: front page image
(EN)Pyridazine compounds represented by the following general formula: (FORMULA) (Wherein Z represents O or H2, n represents 0 or 1, R1 represents H, lower alkyl group, or lower alkanoyl group, R2, R3, R4, and R5 each represents H or lower alkyl group, X1, X2, and X3 each represents H, halogen atom, lower alkyl group, lower alkoxy group, hydroxy group, hydroxyalkoxy group, di-loweralkyl-amino group, lower alkanoylamino group, sulfamoyl group, alkylsulfonylamino group cyano group, nitro group, (R6) (R7)N-(CH2)m-0-, or (R8)(R9)N-CH2CH(OH)-CH2-0-(provided that R6 and R7 each represents H or lower alkyl group, m represents 2 or 3, and R8 and R9 each represents H, unsubstituted lower alkyl group, or 2-methoxy-phenoxy-substituted lower alkyl group), Y represents -CH = CH-, -CH = N-,-O-,-S, or -NH- or, X11 and X2 together may form a methylene-dioxy group), and the pharmaceutically acceptable acid addition salts thereof, which show a hypotensive action and an action of depressing blood platelet agglutination.
(FR)Les composes de pyridazine representes par la formule generale suivante: (FORMULE) (ou Z represente O ou H2, n est 0 ou 1, R1 represente H, un groupe alkyle inferieur, ou un groupe alkanoyle inferieur, R2, R3, R4, et R5 represente chacun H ou un groupe alkyle inferieur, X1, X2 et X3 representent chacun H, un atome d"halogene, un groupe alkyle inferieur, un groupe alkoxy inferieur, un groupe hydroxy, un groupe hydroxyalkoxy, un groupe dialkylamino inferieur, un groupe alkanoylamino inferieur, un groupe sulfamoyle, un groupe alkylsulfonylamino un groupe cyano, un groupe nitro, (R6) (R7) N-(CH2) m-O-, ou (R8) (R9) N-CH2CH (OH)-CH2-O-(R6 et R7 representent chacun H ou un groupe alkyle inferieur, m valant 2 ou 3, et R8 et R9 representent chacun H, un groupe alkyle inferieur non-substitue, ou un groupe alkyle inferieur substitue par 2-methoxy-phenoxy), Y represente -CH=CH-, -CH=N-, -O-, -S-, ou -N H- ou, X1 et X2 peuvent former ensemble un groupe methylene-dioxy), et leurs sels d"addition acide pharmaceutiquement acceptables, ont une action hypotensive et une action depressive sur l"agglutination des plaquettes sanguines.
Designated States:
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)