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Machine translation
1. (WO1979000796) ERYTHROCYTES SENSITIZED WITH A SINGLE IMMUNOGLOBULIN OR COMPLEMENT COMPONENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1979/000796    International Application No.:    PCT/US1979/000121
Publication Date: 18.10.1979 International Filing Date: 28.02.1979
IPC:
G01N 33/555 (2006.01), G01N 33/96 (2006.01)
Applicants:
Inventors:
Priority Data:
890558 20.03.1978 US
Title (EN) ERYTHROCYTES SENSITIZED WITH A SINGLE IMMUNOGLOBULIN OR COMPLEMENT COMPONENT
(FR) ERYTHROCYTES SENSIBILISES AVEC UNE SEULE IMMUNOGLOBULINE OU UN COMPOSANT COMPLEMENTAIRE
Abstract: front page image
(EN)A set of four cell suspensions containing erythrocytes monospecifically sensitized with IgG, IgM, C3, and C4. The suspensions provide control cells to determine the purity and strength of the antibodies to these immunoglobulins or complement components contained in antisera used for clinical testing. Strict control of the pH, temperature, and EDTA concentration of a solution to which blood is added allows for the elective production of C3- or C4- sensitized cells. Selecting a serum with IgG or IgM antibodies and inactivating undesired proteins permits the production IgG- or IgM-sensitized cells. The resultant cells have agglutination reaction strengths of about 2-4+. Erythrocytes from humans r other animals may undergo the monospecific sensitization. Other human proteins, such as IgA or C5, and plasma proteins from other animals may similarly be attached monospecifically to red blood cells.
(FR)Un groupe de quatre suspensions de cellules contenant des erythrocytes sensibilises monospecifiquement avec IgG, IgM, C3 et C4. Les suspensions fournissent des cellules de controle pour determiner la purete et la resistance des anticorps a ces immunoglobulines ou composants complementaires contenues dans des antiserums utilises dans des essais cliniques. Le controle strict du pH, de la temperature et de la concentration EDTA d"une solution a laquelle du sang a ete ajoute permet la production, au choix, de cellules sensibilisees au C3 ou C4. La selection d"un serum avec des anticorps IgG ou IgM et l"inactivation de proteines indesirables permet la production de cellules sensibilisees au IgG ou IgM. Les cellules obtenues ont des resistances de reaction d"agglutination de 2-4+ environ Des erythrocytes provenant d"etres humains ou d, animaux peuvent etre soumis a la sensibilisation monospecifique. D"autres proteines humaines, telles que IgA ou C5, et des proteines de plasma provenant d"autres animaux peuvent etre liees de la meme facon monospecifiquement a des cellules de sang rouge.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)