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Machine translation
1. (WO1979000609) PREPARATION OF TRICHLORO-S-TRIAZINE ACTIVATED SUPPORTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1979/000609    International Application No.:    PCT/US1979/000081
Publication Date: 23.08.1979 International Filing Date: 09.02.1979
IPC:
B01J 20/32 (2006.01), C08B 37/00 (2006.01), C12N 11/10 (2006.01)
Applicants:
Inventors:
Priority Data:
876240 09.02.1978 US
Title (EN) PREPARATION OF TRICHLORO-S-TRIAZINE ACTIVATED SUPPORTS
(FR) PREPARATION DE SUPPORTS ACTIVES AVEC LA TRIAZINE-S-TRICHLOREE (TST)
Abstract: front page image
(EN)When coupling protein and non-protein affinity ligands to solid-phase supports activated with trichloro-s-triazine (TsT), the TsT activated solid-phase support is prepared by reacting a water-free insoluble solid support with TsT in a nonaqueous medium comprising an organic solvent, neutralizing HCl generated during the reaction with a tertiary amine that does not form an insoluble complex with TsT and washing the resultant TsT activated support with organic solvent. After washing, the TsT activated support may be reacted with a nucleophile in an organic solvent to replace one or both chlorine atoms on the triazine ring.
(FR)Lorsqu"on couple des composes a affinite proteinique et non proteinique a des supports solides, actives avec la triazine-s-trichloree (TsT), le support solide active a la TsT est prepare en faisant reagir un support solide, insoluble, anhydre avec la TsT dans un milieu non aqueux comprenant un solvant organique, en neutralisant le HCL produit au cours de la reaction avec une amine tertiaire qui ne forme pas un complexe insoluble avec la TsT, et en lavant le support active a la TsT, obtenu avec un solvant organique. Apres lavage, on peut faire reagir le support active a la TsT avec un nucleophile dans un solvant organique pour remplacer un ou deux atomes de chlore sur le cycle de la triazine.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)