WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1979000299) PURIFICATION OF FACTOR VIII
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1979/000299    International Application No.:    PCT/GB1978/000038
Publication Date: 31.05.1979 International Filing Date: 10.11.1978
IPC:
C07K 14/755 (2006.01), G01N 27/447 (2006.01), A61K 38/00 (2006.01)
Applicants:
Inventors:
Priority Data:
47933/77 17.11.1977 GB
Title (EN) PURIFICATION OF FACTOR VIII
(FR) PURIFICATION DU FACTEUR VIII
Abstract: front page image
(EN)Purification of Factor VIII containing solutions, such as blood plasma, by continuous flow electrophoresis. Hitherto, purification of such solutions his been performed by methods such as cryoprecipitation which however have the disadvantages of poor recovery. In our invention, this problem is overcome by adjusting the pH of a Factor VIII containing solution to be in a range where the stability of Factor VIII is not adversely affected (e.g. 6 to 9) and then subjecting the solution to continuous flow electrophoresis to give purified Factor VIII fractions. If desired, the fractions may be further purified.
(FR)Purification de solutions contenant le facteur VIII, telles que le plasma sanguin, par electrophorese en debit continu. Jusqu"a present, la purification de telles solutions a ete realisee par des methodes telles que la cryoprecipitation qui presentent cependant l"inconvenient de presenter un faible taux de recuperation. Dans l"invention, ce probleme est surmonte en ajustant le pH d"une solution contenant le facteur VIII de sorte qu"il soit dans une plage telle que la stabilite du facteur VIII ne soit pas affectee (p. ex. de 6 a 9) et ensuite en soumettant la solution a une electrophorese en debit continu de maniere a obtenir des fractions de facteur VIII purifiees. Si on le desire, on peut poursuivre la purification des fractions.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)