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1. (WO1979000116) NEW GLYCOL COMPOUNDS FOR LOWERING THE LIPID CONTENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1979/000116 International Application No.: PCT/CH1978/000015
Publication Date: 08.03.1979 International Filing Date: 28.08.1978
IPC:
C07C 41/26 (2006.01) ,C07C 43/23 (2006.01) ,C07D 213/80 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
41
Preparation of ethers; Preparation of compounds having groups, groups or groups
01
Preparation of ethers
18
by reactions not forming ether-oxygen bonds
26
by introduction of hydroxy or O-metal groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
43
Ethers; Compounds having groups, groups or groups
02
Ethers
20
having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
23
containing hydroxy or O-metal groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78
Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
79
Acids; Esters
80
in position 3
Applicants:
Inventors:
Priority Data:
10498/7729.08.1977CH
Title (EN) NEW GLYCOL COMPOUNDS FOR LOWERING THE LIPID CONTENT
(FR) NOUVEAUX DERIVES DE GLYCOLS ABAISSANT LE TAUX EN LIPIDES
Abstract:
(EN) New glycol compounds of formula (1). (FORMULA) wherein, R1 is hydrogen, alkyl with 1 to 4 atoms of C or aryl R2 is hydrogen or alkyl with 1 to 4 atoms of C R3 is hydrogen or a group of formula (FORMULA) where Z is an alkyl rest, an aryl rest eventually sustituted or a heterocyclic rest, R4 is a rest of formula (FORMULA) where R5 is hydrogen or a chlorine atom or a methyl group, have a significant lowering action on the blood grade of cholesterol and of triglycerides. The preparation of these new compounds is described either by reduction of the corresponding acids, or by reaction of a phenol of formula (FORMULA) with an alcohol of formula (FORMULA) possibly followed by an esterification.
(FR) Les nouveaux derives de glycols de formule (1) (FORMULE) dans laquelle R1 signifie hydrogene, alcoyle avec 1 a 4 atomes de C ou aryle R2 signifie hydrogene ou alcoyle avec 1 a 4 atomes de C R3 signifie hydrogene ou un groupe de formule (FORMULE) ou Z est un reste alcoyle, un reste aryle eventuellement substitue ou un reste heterocyclique, R4 signifie un reste de formule (FORMULE) ou R5 est l"hydrogene ou un atome de chlore ou un groupe methyl, presentent une activite interessante d"abaissement du taux sanguin de cholesterol et des triglycerides. L"on decrit la preparation de ces nouveaux derives soit par reduction des acides correspondants, soit par reaction d"un phenol de formule (FORMULE) avec un alcool de formule (FORMULE) suivie d"une eventuelle esterification.
Designated States:
Publication Language: German (DE)
Filing Language: German (DE)