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1. (WO1979000106) PROCESS FOR PREPARING BIOLOGICAL COMPOSITIONS FOR USE AS A REFERENCE CONTROL IN DIAGNOSTIC ANALYSIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1979/000106 International Application No.: PCT/US1978/000069
Publication Date: 08.03.1979 International Filing Date: 22.08.1978
IPC:
G01N 33/96 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
96
involving blood or serum control standard
Applicants:
Inventors:
Priority Data:
82697322.08.1977US
Title (EN) PROCESS FOR PREPARING BIOLOGICAL COMPOSITIONS FOR USE AS A REFERENCE CONTROL IN DIAGNOSTIC ANALYSIS
(FR) PROCEDE DE PREPARATION DE COMPOSITIONS BIOLOGIQUES UTILISEES COMME CONTROLES-TEMOINS DANS LES ANALYSES DIAGNOSTIQUES
Abstract:
(EN) The present disclosure is directed to the preparation of stable aqueous-containing biological compositions capable of use as liquid reference serum in diagnostic chemical analysis using multichannel automated analyzers and having improved storage stability and capable of storage in the liquid state for extended periods of time measured in weeks when stored at 2 to 8 C.; processes for preparing the reference serums and the process of automated analysis utilizing the improved reference serums. The subject materials are prepared by freezing the aqueous-containing labile biologicals rapidly at temperatures ranging from about -20 to about -30 C., removing from about 98 to 99 weight per cent of the water therefrom and storing same (as a dehydrated solid) at 2 to 8 C. until desired use. The dehydrated material is then reconstituted by dissolving it in a medium containing from about 20 to about 50 weight per cent of an alkylene polyol containing from 2 to 5 carbon atoms with the remainder being water. The thus reconstituted biological compositions can be stored in the liquid state at 2 to 8 C. for periods of 4 to 5 weeks or at -20 C. for months.
(FR) Procedes de preparation de serums temoins et d"analyse automatisee utilisant les serums temoins ameliores qui consistent en des compositions biologiques aqueuses stables pouvant etre utilisees comme serums temoins liquides dans les analyses chimiques diagnostiques ayant recours a des analyseurs automatiques a plusieurs canaux, lesdites compositions ayant une meilleure stabilite de conservation et susceptibles d"etre conservees a l"etat liquide pendant des periodes de temps prolongees equivalentes a plusieurs semaines lorsqu"elles sont conservees entre 2 C et 8 C. Les matieres en question sont preparees en congelant rapidement les substances biologiques labiles aqueuses a des temperatures allant de -20 C a -30 C environ, en enlevant de ces substances 98% a 99% en poids d"eau et en les conservant (sous forme d"un solide deshydrate) entre 2 C et 8 C, jusqu"a utilisation, Le materiau deshydrate est ensuite reconstitue en le dissolvant dans un milieu contenant entre 20% et 50% environ en poids d"un polyol d"alcoylene contenant de 2 a 5 atomes de carbone, l"eau constituant la balance. Les compositions biologiques ainsi reconstituees peuvent etre conservees a l"etat liquide entre 2 C et 8 C pendant des periodes de 4 a 5 semaines ou a 20 C pendant des mois.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)