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1. (WO1979000081) 6,8B-ETHANO-8BH-CYCLOPENTA(DE)(2)BENZOPYRAN-1,4-DIONE DERIVATIVE,PREPARATION AND USE THEREOF
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WHAT IS CLAIMED IS:

1. The process of producing a complex quadracyclic lactone designated as quadrone, which comprises cultivating the microorganism Aspergillus terreus NRRL 11156 under submerged aerobic conditions in an aqueous carbohydrate solution containing a nitrogenous nutrient until a
substantial amount of quadrone is produced.
2. A method as in Claim 1 wherein the microorganism is cultured at a temperature of from about 22° to about 30° C. for from about 4 to 15 days.
3. A method as in Claim 1 including the additional step of recovering quadrone from the fermentation broth.
4. A method as in Claim 1 wherein the microorganism is cultured at about 25° C.
5. A method as in Claim 1 wherein the microorganism is cultured until the level of quadrone in the fermentation broth is at least 0.001 mg./ml.
6. Octahydro-10, 10-dimethyl-6,8b-ethano-8bH- cyclopenta[de] [2]benzopyran-1,4-dione corresponding to the structural formula:

7. A method of inhibiting the growth of tumor cells comprising inoculating said cells with an effective amount of octahydro-10, 10-dimethyl-6,8b-ethano-8bH-cyclopenta [de] [2]benzopyran-1,4-dione.