Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO18207165) NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/207165 International Application No.: PCT/IB2018/053357
Publication Date: 15.11.2018 International Filing Date: 14.05.2018
IPC:
C07D 499/90 (2006.01) ,C07D 513/20 (2006.01) ,A61P 31/18 (2006.01) ,A61K 31/431 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
499
Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
90
further condensed with carbocyclic rings or ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
12
in which the condensed system contains three hetero rings
20
Spiro-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
429
condensed with heterocyclic ring systems
43
Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
431
containing further heterocyclic ring systems, e.g. ticarcillin, azlocillin, oxacillin
Applicants:
UNIVERSIDADE DE COIMBRA [PT/PT]; Paço Das Escolas 3004-531 Coimbra, PT
FACULDADE DE FARMÁCIA DA UNIVERSIDADE DE LISBOA [PT/PT]; Av. Professor Gama Pinto 1649-003 Lisboa, PT
EGAS MONIZ - COOPERATIVA DE ENSINO SUPERIOR, CRL [PT/PT]; Campus Universitário, Quinta Da Granja, Monte De Caparica 2829-511 Caparica, PT
INSTITUTO DE MEDICINA MOLECULAR [PT/PT]; Av. Prof. Egas Moniz | Ed. Egas Moniz 1649-028 Lisboa, PT
Inventors:
VASCONCELOS DIAS DE PINHO E MELO, Teresa Margarida; PT
C. SUZANO SANTOS, Bruna; PT
BÁRTOLO, Inês; PT
PRUDÊNCIO PIGNATELLI, Rui Miguel; PT
MOURA DOS SANTOS DA COSTA TAVEIRA, Nuno Eduardo; PT
Agent:
TEIXEIRA DE CARVALHO, Anabela; PT
Priority Data:
11007012.05.2017PT
Title (EN) NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF
(FR) NOUVEAUX COMPOSÉS SPIRO-LACTAMES, PROCÉDÉS ET UTILISATIONS ASSOCIÉS
Abstract:
(EN) The present disclosure relates to a new class of antimicrobial agents. In particular, this disclosure provides the identification and characterization of novel spiro-lactam compoundsas anti-HIV/AIDS and anti-malarial agents. Furthermore, this disclosure also provides the preparation of spiro-β-penicillanic acids, which proved to be potent inhibitors of HIV.
(FR) La présente invention concerne une nouvelle classe d'agents antimicrobiens. La présente invention concerne particulièrement l'identification et la caractérisation de nouveaux composés spiro-lactames, anti-VIH/SIDA et agents antipaludiques. La présente invention concerne également la préparation d'acides spiro-bêta-pénicillaniques, qui se sont avérés être des inhibiteurs puissants du VIH.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)