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1. (US20140045741) Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease

Application Number: 14059035 Application Date: 21.10.2013
Publication Number: 20140045741 Publication Date: 13.02.2014
Publication Kind : A1
IPC:
A61K 38/13
Applicants: Howard University
Inventors: Karla Pradeep K.
Mangat Harpal S.
Priority Data:
Title: (EN) Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease
Abstract:
(EN)

Methods and compositions are provided for treating an ocular disease in a subject in need thereof by increasing the bioavailability of a drug in the subject's eye. In one aspect, the ocular disease is at least one of diabetic retinopathy, macular degeneration, endopthalmitis, glaucoma, cataracts, ocular herpes. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for treating the ocular disease. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).