US20140018345 Inhibition of enzymes

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United States of America

Application Number 13940555

Application Date 12.07.2013

Publication Number 20140018345

Publication Date 16.01.2014

Grant Number 09199984

Grant Date 01.12.2015

Publication Kind B2

IPC

CPC

Applicants CHIESI FARMACEUTICI S.p.A.

Inventors Carmelida Capaldi
Robert Andrew Heald
Nicholas Charles Ray
Jonathan Mark Sutton

Agents Oblon, McClelland, Maier & Neustadt, L.L.P.

Priority Data 12176079 12.07.2012 EP
13158756 12.03.2013 EP

Title

(EN) Inhibition of enzymes

Abstract

(EN)

Compounds of formula (I):

wherein R₁, R₂, R₃, R₅, R₆, A₁, A₂, A₃, A₄assume meanings as defined in formula (I) are inhibitors of neutrophil elastase.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02	containing two hetero rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02	containing two hetero rings
10	linked by a carbon chain containing aromatic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14	containing three or more hetero rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
4353	ortho- or peri-condensed with heterocyclic ring systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
4353	ortho- or peri-condensed with heterocyclic ring systems
437	the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline