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1. US20130225810 - Benzamide derivative with anticancer activity and preparation method and use thereof

Office United States of America
Application Number 13883520
Application Date 03.11.2011
Publication Number 20130225810
Publication Date 29.08.2013
Grant Number 08946478
Grant Date 03.02.2015
Publication Kind B2
IPC
C07C 255/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
58containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
60at least one of the singly-bound nitrogen atoms being acylated
C07C 233/65
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
65having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
C07D 295/192
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16acylated on ring nitrogen atoms
18by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
182Radicals derived from carboxylic acids
192from aromatic carboxylic acids
C07C 231/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
02from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 233/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
90having nitrogen atoms of carboxamide groups further acylated
92with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 253/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
CPC
C07C 255/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
58containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
60at least one of the singly-bound nitrogen atoms being acylated
C07C 231/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
02from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 233/65
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
65having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
C07C 233/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
90having nitrogen atoms of carboxamide groups further acylated
92with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 253/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
C07C 255/57
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
57containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
Applicants Bai Hua
Zhejiang Hisun Pharmaceutical Co., Ltd.
Zhao Xuyang
Gong Yongxiang
Zhong Jinqing
Zhu Qifeng
Liu Xiaoyu
Liu Lifei
Zhou Qixian
Inventors Bai Hua
Zhao Xuyang
Gong Yongxiang
Zhong Jinqing
Zhu Qifeng
Liu Xiaoyu
Liu Lifei
Zhou Qixian
Agents Wolf, Greenfield & Sacks, P.C.
Priority Data 2010 1 0532658 05.11.2010 CN
Title
(EN) Benzamide derivative with anticancer activity and preparation method and use thereof
Abstract
(EN)

Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description.

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