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1. US20130178654 - Process for cinacalcet hydrochloride

Office
United States of America
Application Number 13810319
Application Date 16.07.2010
Publication Number 20130178654
Publication Date 11.07.2013
Grant Number 08921606
Grant Date 30.12.2014
Publication Kind B2
IPC
C07C 45/41
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
41by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
C07C 209/70
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
68from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
70by reduction of unsaturated amines
C07C 209/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
82Purification; Separation; Stabilisation; Use of additives
84Purification
C07C 209/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
24by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
28by reduction with other reducing agents
CPC
C07C 45/41
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
41by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
C07C 209/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
24by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
28by reduction with other reducing agents
C07C 209/70
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
68from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
70by reduction of unsaturated amines
C07C 209/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
82Purification; Separation; Stabilisation; Use of additives
84Purification
Applicants Parthasaradhi Reddy Bandi
Hetero Research Foundation
Rathnakar Reddy Kura
Muralidhara Reddy Dasari
Raji Reddy Rapolu
Mukunda Reddy Jambula
Vamsi Krishna Bandi
Inventors Parthasaradhi Reddy Bandi
Rathnakar Reddy Kura
Muralidhara Reddy Dasari
Raji Reddy Rapolu
Mukunda Reddy Jambula
Vamsi Krishna Bandi
Agents Choate Hall & Stewart LLP
Lyon Charles E.
McLean Thomas H.
Title
(EN) Process for cinacalcet hydrochloride
Abstract
(EN)

3-[3-(Trifluoromethyl)phenyl]propionaldehyde is a key intermediate for the preparation of cinacalcet hydrochloride. The present invention provides a novel process for the preparation of 3-[3-(trifluoromethyl)phenyl]propionaldehyde. The present invention also provides an improved process for preparation of cinacalcet hydrochloride in high yields. The present invention further provides a process for purification of cinacalcet hydrochloride.


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