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1. US20120329852 - Composition for preventing the occurrence of cardiovascular event in multiple risk patient

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Claims

1. A method of reducing occurrence of a cardiovascular event in a hypercholesterolemia patient comprising,
identifying a patient having triglycerides (TG) of at least 150 mg/DL, and HDL-C of less than 40 mg/dL in a blood sample taken from the patient as the only risk factor of a cardiovascular event, wherein the patient has not previously had a cardiovascular event, and administering ethyl icosapentate in combination with a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor;
wherein the rate of suppression of the cardiovascular event occurrence in the said administered patient group is equal to or more than 48% compared to the control patient group after 2 years or more from the start of said administration; and
wherein the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor is selected from the group consisting of pravastatin, lovastatin, simvastatin, fluvastatin, atorvastatin, pitavastatin, rosuvastatin, and salts thereof.
2. The method according to claim 1, wherein the content of the ethyl icosapentate is at least 96.5% by weight in relation to the total content of fatty acid that is simultaneously administered with the ethyl icosapentate.
3. The method according to claim 1, wherein the ethyl icosapentate is orally administered at a dose of 1.8 g/day to 2.7 g/day.
4. The method according to claim 1, wherein the hypercholesterolemia patient is a male patient.
5. The method according to claim 1, which comprises administering the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor to the patient at least one of before, during and after administering the ethyl icosapentate.
6. The method according to claim 1, wherein the ethyl icosapentate is administered daily for two years or more.
7. The method according to claim 1, wherein the cardiovascular event is a fatal cardiovascular event.
8. The method according to claim 1, wherein the hypercholesterolemia patient has a serum [triglyceride (TG)/HDL-C] ratio of at least 3.75.
9. The method according to claim 1,wherein the ethyl icosapentate is orally administered at a dose of 0.3 g/day to 6 g/day.