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1. US20120308599 - Vaccine and methods of use against Strongyloide stercoralis infection

Office
United States of America
Application Number 13575987
Application Date 01.02.2011
Publication Number 20120308599
Publication Date 06.12.2012
Grant Number 09056068
Grant Date 16.06.2015
Publication Kind B2
IPC
A61K 39/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/435
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
CPC
A61K 39/0003
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0003Invertebrate antigens
C07K 14/4354
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
43536from worms
4354from nematodes
Applicants Thomas B. Nutman
The United States of America, as represented by the Secretary, Department of Health and Human Services
David Abraham
Thomas Jefferson University
Inventors Thomas B. Nutman
David Abraham
Agents Leydig, Voit & Mayer, Ltd.
Title
(EN) Vaccine and methods of use against Strongyloide stercoralis infection
Abstract
(EN)

The polynucleotide encoding the SSIR gene from the nematode Strongyloides stercoralis is provided, along with the polypeptide encoded by the SSIR gene. It was found that when mice were immunized with the SSIR polypeptide vaccine, it provided immunity to mice which were implanted with Strongyloides stercoralis L3 implants. Methods for making the SSIR protein, recombinant vectors encoding the SSIR gene, a vaccine made from the SSIR protein, and methods of use are also provided.


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