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1. (US20120071486) Thienopyrimidine compounds and use thereof

Office : United States of America
Application Number: 13242541 Application Date: 23.09.2011
Publication Number: 20120071486 Publication Date: 22.03.2012
Grant Number: 08735401 Grant Date: 27.05.2014
Publication Kind : B2
IPC:
A61K 31/519
A61P 35/04
C07D 495/04
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
CPC:
C07D 495/04
A61K 31/519
Applicants: Cho Nobuo
Takeda Pharmaceutical Company Limited
Imada Takashi
Hitaka Takenori
Miwa Kazuhiro
Kusuka Masami
Suzuki Nobuhiro
Inventors: Cho Nobuo
Imada Takashi
Hitaka Takenori
Miwa Kazuhiro
Kusuka Masami
Suzuki Nobuhiro
Agents: Edwards Wildman Palmer LLP
Conlin David G.
Koundakjian Edmund J.
Priority Data: 2003-020854 29.01.2003 JP
Title: (EN) Thienopyrimidine compounds and use thereof
Abstract: front page image
(EN)

The present invention provides a compound represented by the formula:

embedded image
wherein R1 is a C1-4 alkyl; R2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a hydroxy group, (3′) a C1-4 alkyl and (4′) a C1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a C1-4 alkoxy-C1-4 alkyl, (3′) a mono-C1-4 alkyl-carbamoyl-C1-4 alkyl, (4′) a C1-4 alkoxy and (5′) a mono-C1-4 alkylcarbamoyl-C1-4 alkoxy, or the like; R3 is a C1-4 alkyl; R4 is a C1-4 alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.


Also published as:
NO20053974PL378002PLP.378002MXPA/a/2005/007990KR1020050096171ZA2005/06611
IL169869BRPI0407082CO5590921EP1591446JP2004250439JP2008094846
RU02331648US20060160829US20080108623CN1768065CA2514407ES2410814
US20140221381PT1591446NZ541772DK1591446AU2004207706BNRE/2013/0034
ID047.1556BRPI0407082WO/2004/067535