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1. (US20110313176) PROCESSES FOR PREPARING HIGHLY PURE ROTIGOTINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Office : United States of America
Application Number: 13141151 Application Date: 22.12.2009
Publication Number: 20110313176 Publication Date: 22.12.2011
Publication Kind : A1
Prior PCT appl.: Application Number:PCTIB2009007975 ; Publication Number: Click to see the data
IPC:
C07D 333/20
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
14
Radicals substituted by singly bound hetero atoms other than halogen
20
by nitrogen atoms
Applicants: ACTAVIS GROUP PTC EHF
Inventors: Khunt Mayur Devjibhai
Varma Shrikant
Patil Nilesh Sudhir
Pagire Haushabhau Shivaji
Pradhan Nitin Sharadchandra
Priority Data: 200/CHE/2009 29.01.2009 IN
3286/CHE/2008 26.12.2008 IN
Title: (EN) PROCESSES FOR PREPARING HIGHLY PURE ROTIGOTINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Abstract:
(EN)

Provided herein are convenient, industrially advantageous and environmentally friendly processes for the preparation of (−)-(S)-5-hydroxy-2-[N-n-propyl-N-2-(2-thienyl)ethylamino]tetralin (rotigotine) or a pharmaceutically acceptable salt thereof. Provided further herein is a highly pure rotigotine or a pharmaceutically acceptable salt thereof substantially free of impurities, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure rotigotine or a pharmaceutically acceptable salt thereof substantially free of impurities.


Also published as:
WO/2010/073124