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1. US20110307073 - Resorbable scaffolds for bone repair and long bone tissue engineering

Office United States of America
Application Number 13124161
Application Date 19.10.2009
Publication Number 20110307073
Publication Date 15.12.2011
Grant Number 08702808
Grant Date 22.04.2014
Publication Kind B2
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02
Prostheses implantable into the body
28
Bones
A61F 2/28
CPC
A61F 2/28
A61F 2/3094
A61F 2002/30062
A61F 2002/30235
A61F 2002/3024
A61F 2002/3092
Applicants Teoh Swee Hin
Osteopore International PTE Ltd
Song Hae-Ryong
Osteopore Korea Co. Ltd
Yew Soi Khoon
National University of Singapore
Koh Kelvin Hong Yap
Bae Ji Hoon
Wang Joon Ho
Inventors Teoh Swee Hin
Song Hae-Ryong
Yew Soi Khoon
Koh Kelvin Hong Yap
Bae Ji Hoon
Wang Joon Ho
Agents Hamilton, Brook, Smith & Reynolds, P.C.
Title
(EN) Resorbable scaffolds for bone repair and long bone tissue engineering
Abstract
(EN)

Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.

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