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1. US20110142948 - Nanoparticle carrier systems based on human serum albumin for photodynamic therapy

Office
United States of America
Application Number 12941350
Application Date 08.11.2010
Publication Number 20110142948
Publication Date 16.06.2011
Grant Number 09211283
Grant Date 15.12.2015
Publication Kind B2
IPC
A61K 9/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 31/409
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
409having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
A61K 33/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
20Elemental chlorine; Inorganic compounds releasing chlorine
A61K 41/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
Applicants Klaus Langer
Biolitec Pharma Marketing Ltd
Matthias Wacker
Beate Röder
Annegret Preuss
Volker Albrecht
Susanna Gräfe
Arno Wiehe
Hagen von Briesen
Karin Löw
Sylvia Wagner
Inventors Klaus Langer
Matthias Wacker
Beate Röder
Annegret Preuss
Volker Albrecht
Susanna Gräfe
Arno Wiehe
Hagen von Briesen
Karin Löw
Sylvia Wagner
Agents B J Associates
Bolesh J. Skutnik
Title
(EN) Nanoparticle carrier systems based on human serum albumin for photodynamic therapy
Abstract
(EN)

Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.