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1. (US20110059978) Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors

Office : United States of America
Application Number: 12946271 Application Date: 15.11.2010
Publication Number: 20110059978 Publication Date: 10.03.2011
Grant Number: 08410105 Grant Date: 02.04.2013
Publication Kind : B2
IPC:
C07D 401/14
A61K 31/501
A61P 31/12
A61P 9/02
A61P 1/16
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
02
Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants: Li Song
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
Mi Chunlai
Zheng Zhibing
Zhao Guoming
Zhou Xinbo
Gong Zehui
Inventors: Li Song
Mi Chunlai
Zheng Zhibing
Zhao Guoming
Zhou Xinbo
Gong Zehui
Agents: Ladas & Parry LLP
Priority Data: 200510081813.9 30.06.2005 CN
Title: (EN) Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors
Abstract: front page image
(EN)

The present invention relates to substituted pyridazinylamine derivatives of the formula I or pharmaceutically acceptable salts or hydrates thereof, wherein the substituents are defined as in the description, their preparation process, pharmaceutical compositions comprising them, and uses of the said compounds as picorna virus inhibitors for prevention and/or treatment of diseases caused by picorna viruses.

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Also published as:
KR1020080045120EP1900735JP2008546814RU02380366US20080269232ES2386550
AU2005334058DK1900735IN636/DELNP/2008WO/2007/003077