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1. US20110021529 - P53 activating compounds

Office
United States of America
Application Number 12439906
Application Date 04.09.2007
Publication Number 20110021529
Publication Date 27.01.2011
Grant Number 08501991
Grant Date 06.08.2013
Publication Kind B2
IPC
C07C 335/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
335Thioureas, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
04Derivatives of thiourea
16having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
C07D 295/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
12substituted by singly or doubly bound nitrogen atoms
A61K 31/5375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
A61K 31/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
Applicants Lain Sonia
University Court of the University of Dundee
Lane David Phillip
University Court of the University of St. Andrews
Stark Michael John Raymond
McCarthy Anna Rose
Hollick Jonathan James
Westwood Nicholas James
Inventors Lain Sonia
Lane David Phillip
Stark Michael John Raymond
McCarthy Anna Rose
Hollick Jonathan James
Westwood Nicholas James
Agents Myers Bigel Sibley & Sajovec, P.A.
Priority Data 0617278.7 04.09.2006 GB
0625929.5 23.12.2006 GB
Title
(EN) P53 activating compounds
Abstract
(EN)

The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).