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230. (US20110021497) Amino triazoles as PI3K inhibitors

Pub. No.:    20110021497    International Application No.:    12744940
Publication Date: Fri Jan 28 00:59:59 CET 2011 International Filing Date: Sat Nov 22 00:59:59 CET 2008
IPC: A01N 43/42
A61K 31/44
C07D 471/02
C07D 491/02
C07D 498/02
Applicants: Ramsden Nigel
Cellzome Ltd.
Bell Kathryn
Cansfield Andrew David
Taylor Jess
Sunose Mihiro
Middlemiss David
Neubauer Gitte
Inventors: Ramsden Nigel
Bell Kathryn
Cansfield Andrew David
Taylor Jess
Sunose Mihiro
Middlemiss David
Neubauer Gitte
Title: Amino triazoles as PI3K inhibitors
Abstract:

The invention relates to compounds of formula (I)

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wherein X, T1 and R1 to R3 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of PI3K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.