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1. US20100215695 - HIV PREVENTIVE VACCINE BASED ON HIV SPECIFIC ANTIBODIES

Office
United States of America
Application Number 12526038
Application Date 09.10.2008
Publication Number 20100215695
Publication Date 26.08.2010
Publication Kind A1
IPC
A61K 39/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
Applicants TECHNOLOGIE INTEGRALE LIMITED
Inventors Filinova Elena Yu.
Agents KNOBBE MARTENS OLSON &; BEAR LLP
Title
(EN) HIV PREVENTIVE VACCINE BASED ON HIV SPECIFIC ANTIBODIES
Abstract
(EN)

The present invention relates to a method for producing a HIV vaccine, preventing infection with HIV and/or preventing the development of HIV infection in an individual. In particular, the present invention provides formation of HIV specific antibodies capable to recognize and bind to substantially all HIV-isoforms as an immune response in an individual, which bind to existing in a current epidemiologic cohort HIV-subtypes and mutants selected after antiretroviral therapy. The present invention also relates to HIV-1 peptides/polypeptides/proteins selection with reverse panning technique, LC mass spectrometry identification of HIV-1 env peptides/polypeptides/proteins, gp120 and its fragment in particular, production of recombinant HIV-1 env peptides in suitable host with necessary glycosylation—L. tarentolae and using sterically stabilized liposomes (SSL) as an adjuvant-carrier for HIV-specific immune boost composition.


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