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1. US20090047675 - Compositions and methods for identifying transforming and tumor suppressor genes

Office
United States of America
Application Number 12150941
Application Date 01.05.2008
Publication Number 20090047675
Publication Date 19.02.2009
Grant Number 08178317
Grant Date 15.05.2012
Publication Kind B2
IPC
C12P 21/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
06produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
Applicants Dana-Farber Cancer Institute, Inc.
Inventors Roberts Thomas M.
Zhao Jean
Hill David E.
Hahn William C.
Boehm Jesse
Agents Foley Hoag LLP
Title
(EN) Compositions and methods for identifying transforming and tumor suppressor genes
Abstract
(EN)

Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complementing genes directly as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics. Further provided are methods for using changes caused by expression of the complementing genes to indirectly identify associated genes to be used as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics.


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