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Machine translation
9. (US20090324638) LIVE BACTERIAL VACCINE

Application Number: 12304634 Application Date: 12.06.2006
Publication Number: 20090324638 Publication Date: 31.12.2009
Publication Kind : A1
PCT Reference: Application Number:US07013753 ; Publication Number: Click to see the data
IPC:
A61K 39/02
A61P 31/00
A61P 31/04
C12N 1/21
CPC:
A61K 39/025
A61K 39/0225
A61K2039/523
Applicants: Biopeptides Corp.
Lactrys Octrooi BV
Inventors: Dattwyler Raymond J.
Gomes-Solecki Maria J.C.
Seegers Jozef F.M.L.
Agents: VENABLE LLP
Priority Data:
Title: (EN) LIVE BACTERIAL VACCINE
Abstract:
(EN)

The present invention relates, e.g., to a Lactobacillus bacterium, which (1) expresses a recombinant polypeptide containing a lipoprotein signal sequence from the OspA protein of Borrelia burgdorferi, or an active variant of the leader sequence, operably linked to one or more heterologous polypeptide(s) of interest and/or (2) which comprises an expressible polynucleotide encoding a recombinant polypeptide, wherein the polynucleotide encodes a lipoprotein signal from the OspA protein of Borrelia burgdorferi, or an active variant thereof, which is operably linked to one or more heterologous polypeptide(s) of interest. In one embodiment, the heterologous polypeptide is from Yersinia pestis, the etiologic agent of plague. In another embodiment, the heterologous polypeptide is from Borrelia burgdorferi, the etiologic agent of Lyme disease. Also described are immunogenic compositions, such as live bacterial vaccines, comprising the bacterium; methods for eliciting an immune response against the polypeptide using the bacterium; and kits comprising the bacterium.