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1. (US20090143359) Percutaneously Absorptive Ophthalmic Preparation Comprising Epinastine

Office : United States of America
Application Number: 11988390 Application Date: 07.07.2006
Publication Number: 20090143359 Publication Date: 04.06.2009
Publication Kind : A1
Prior PCT appl.: Application Number:JP06314005 ; Publication Number: Click to see the data
IPC:
A61K 31/55
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
Applicants:
Inventors: Isowaki Akiharu
Nakajima Tomoko
Ohtori Akira
Agents: WENDEROTH, LIND &; PONACK, L.L.P.
Priority Data:
Title: (EN) Percutaneously Absorptive Ophthalmic Preparation Comprising Epinastine
Abstract:
(EN)

The present invention provides a percutaneously absorptive preparation for preventing or treating allergic eye disease, which comprises epinastine or a salt thereof as an active ingredient. In addition, the present invention provides a method for preventing or treating allergic eye disease, which comprises applying a percutaneously absorptive preparation comprising epinastine or a salt thereof to the skin surface including the skin surface of an eyelid, thereby causing transfer of a therapeutically effective amount of epinastine or a salt thereof from the preparation to an anterior ocular segment through the skin of the eyelid rather than a systemic blood flow. The present preparation can exert a pharmacological effect over a prolonged period by a single application, as compared to conventional preparations such as eye drops.


Also published as:
KR1020080034916EP1901724JP2009500397CN101217948IN687/CHENP/2008WO/2007/007851