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1. (US20070269438) Antibodies to the human prolactin receptor

Office : United States of America
Application Number: 11538635 Application Date: 04.10.2006
Publication Number: 20070269438 Publication Date: 22.11.2007
Grant Number: 7422899 Grant Date: 09.09.2008
Publication Kind : B2
IPC:
C12N 5/00
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
CPC:
C07K 16/2869
A61K 2039/505
C07K 2317/73
C07K 2317/76
Applicants: Biogen Idec MA Inc.
Inventors: Elenbaas Brian
Jarpe Matthew B
Miklasz Steven D.
Fawell Stephen E.
Agents: Fish &; Richardson P.C.
Priority Data: 60724054 05.10.2005 US
Title: (EN) Antibodies to the human prolactin receptor
Abstract: front page image
(EN)

This invention provides antibodies to the prolactin receptor, particularly the human prolactin receptor. Preferred antibodies are capable of blocking prolactin binding to the prolactin receptor, inhibiting signaling through the prolactin receptor, and/or inhibiting proliferation of cancer cells induced by prolactin. Also provided are nucleic acids encoding the antibodies, vectors and host cells comprising the nucleic acids, and uses of the antibodies and nucleic acids.