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1. (US20070243194) Anti-IGF-1R antibodies and uses thereof

Office : United States of America
Application Number: 11727887 Application Date: 28.03.2007
Publication Number: 20070243194 Publication Date: 18.10.2007
Grant Number: 7612178 Grant Date: 03.11.2009
Publication Kind : B2
IPC:
C07K 16/00
C12P 21/08
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
CPC:
C07K 16/2863
A61K 2039/505
C07K 2317/21
C07K 2317/24
C07K 2317/33
C07K 2317/34
C07K 2317/41
C07K 2317/52
C07K 2317/524
C07K 2317/53
C07K 2317/55
C07K 2317/73
C07K 2317/76
C07K 2317/77
C07K 2317/92
C07K 2319/00
Applicants: Biogen Idec MA Inc
Inventors: Hariharan Kandasamy
Glaser Scott
Garber Ellen
Graff Christilyn
Reyes Christopher L.
Demarest Stephen
Agents: Sterne, Kessler, Goldstein & Fox P.L.L.C.
Priority Data:
Title: (EN) Anti-IGF-1R antibodies and uses thereof
Abstract: front page image
(EN)

The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.