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1. (US20070021504) Composition and/or method for preventing onset and/or recurrence of cardiovascular events
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Claims

1. A method for preventing onset and/or recurrence of cardiovascular events in a patient who has escaped the unstable period after cardiovascular angioplasty, comprising starting to administer a composition containing ethyl icosapentate as an effective component thereof to the patient to prevent percutaneous transluminal coronary angioplasty (PTCA) after the patient has escaped the unstable period.
2. The method according to claim 1, wherein the cardiovascular angioplasty is selected from the group consisting of percutaneous transluminal coronary angioplasty (PTCA), percutaneous transluminal coronary recanalization (PTCR), directional coronary atherectomy (DCA), coronary stent implantation (coronary artery stenting), and coronary artery bypass grafting (AC bypass grafting).
3. The method of claim 2, wherein said patient has received percutaneous transluminal coronary angioplasty (PTCA).
4. The method of claim 1, wherein said patient is suffering from hyperlipidemia.
5. The method of claim 1, wherein said patient is not also administered a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
6. The method of claim 1, wherein said patient has received percutaneous transluminal coronary angioplasty (PTCA);
said patient is suffering from hyperlipidemia; and
the patient is not also administered a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
7. The method according to claim 1, wherein the composition is administered to the patient for at least one year.
8. The method according to claim 1, wherein the composition is administered to the patient for at least two years.
9. The method according to claim 1, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 0.9 to 3.6 g/day.
10. The method according to claim 1, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 1.8 to 2.7 g/day.
11. The method according to claim 1, wherein the cardiovascular event is not restenosis.
12. A method for preventing onset and/or recurrence of cardiovascular events in a patient after six months have passed since the cardiovascular angioplasty, comprising starting to administer a composition containing ethyl icosapentate as an effective component thereof to the patient to prevent percutaneous transluminal coronary angioplasty (PTCA) after six months have passed since the cardiovascular angioplasty.
13. The method according to claim 12, wherein the cardiovascular angioplasty is selected from the group consisting of percutaneous transluminal coronary angioplasty (PTCA), percutaneous transluminal coronary recanalization (PTCR), directional coronary atherectomy (DCA), coronary stent implantation(coronary artery stenting), and coronary artery bypass grafting (AC bypass grafting).
14. The method according to claim 13,
wherein said composition further contains other fatty acids or derivatives thereof,
the proportion of the ethyl icosapentate in the total content of fatty acids and derivatives thereof is 96.5% by weight or more, and
the ethyl icosapentate being orally administered at an amount of 0.3 g/day to 6.0 g/day.
15. The method of claim 13, wherein said patient has received percutaneous transluminal coronary angioplasty (PTCA).
16. The method according to claim 12, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 0.3 g/day to 6.0 g/day.
17. The method according to claim 12, wherein the composition is used in combination with an inhibitor for 3-hydroxy-3-methylglutaryl coenzyme A reductase.
18. The method according to claim 17, wherein the cardiovascular angioplasty is percutaneous transluminal coronary angioplasty (PTCA), percutaneous transluminal coronary recanalization (PTCR), directional coronary atherectomy (DCA), coronary stent implantation(coronary artery stenting), or coronary artery bypass grafting (AC bypass grafting).
19. The method according to claim 18, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 0.3 g/day to 6.0 g/day.
20. The method according to claim 19, wherein the proportion of the ethyl icosapentate in the total content of fatty acids and derivatives thereof is 96.5% by weight or more.
21. The method according to claim 19, wherein the patient suffers from hyperlipidemia.
22. The method according to claim 17, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 0.3 g/day to 6.0 g/day.
23. The method according to claim 17, wherein the inhibitor is pravastatin, simvastatin, or atorvastatin calcium hydrate.
24. The method according to claim 23, wherein the proportion of the ethyl icosapentate in the total content of fatty acids and derivatives thereof is 96.5% by weight or more.
25. The method according to claim 23, wherein the patient suffers from hyperlipidemia.
26. The method of claim 12, wherein said patient is suffering from hyperlipidemia.
27. The method of claim 12, wherein said patient is not also administered a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
28. The method of claim 12, wherein said patient has received percutaneous transluminal coronary angioplasty (PTCA);
said patient is suffering from hyperlipidemia; and
the patient is not also administered a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
29. The method according to claim 12, wherein the composition is administered to the patient for at least one year.
30. The method according to claim 12, wherein the composition is administered to the patient for at least two years.
31. The method according to claim 12, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 0.9 to 3.6 g/day.
32. The method according to claim 12, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 1.8 to 2.7 g/day.
33. The method according to claim 12, wherein the cardiovascular event is not restenosis.
34. A method for preventing onset and/or recurrence of cardiovascular events in a patient who has history of cardiovascular angioplasty, comprising starting to administer a composition containing ethyl icosapentate as an effective component thereof to the patient to prevent percutaneous transluminal coronary angioplasty (PTCA) after six months have passed since the cardiovascular angioplasty and continuing the administration at least for two years.
35. The method according to claim 34, wherein the cardiovascular angioplasty is selected from the group consisting of percutaneous transluminal coronary angioplasty (PTCA), percutaneous transluminal coronary recanalization (PTCR), directional coronary atherectomy (DCA), coronary stent implantation(coronary artery stenting), and coronary artery bypass grafting (AC bypass grafting).
36. The method according the claim 35,
wherein said composition further contains other fatty acids or derivatives thereof,
the proportion of the ethyl icosapentate in the total content of fatty acids and derivatives thereof is 96.5% by weight or more, and
the ethyl icosapentate being orally administered at an amount of 0.3 g/day to 6.0 g/day.
37. The method of claim 35, wherein said patient has received percutaneous transluminal coronary angioplasty (PTCA).
38. The method according to claim 34, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 0.3 g/day to 6.0 g/day.
39. The method according to claim 34, wherein the composition is used in combination with an inhibitor for 3-hydroxy-3-methylglutaryl coenzyme A reductase.
40. The method according to claim 39, wherein the cardiovascular angioplasty is selected from the group consisting of percutaneous transluminal coronary angioplasty (PTCA), percutaneous transluminal coronary recanalization (PTCR), directional coronary atherectomy (DCA), coronary stent implantation(coronary artery stenting), and coronary artery bypass grafting (AC bypass grafting).
41. The method according to claim 40, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 0.3 g/day to 6.0 g/day.
42. The method according to claim 41, wherein the proportion of the ethyl icosapentate in the total content of fatty acids and derivatives thereof is 96.5% by weight or more.
43. The method according to claim 41, wherein the patient suffers from hyperlipidemia.
44. The method according to claim 39, wherein the amount of ethyl icosapentate in the composition is orally administered at an amount of 0.3 g/day to 6.0 g/day.
45. The method according to claim 39, wherein the inhibitor is pravastatin, simvastatin, or atorvastatin calcium hydrate.
46. The method according claim 45, wherein the proportion of the ethyl icosapentate in the total content of fatty acids and derivatives thereof is 96.5% by weight or more.
47. The method according to claim 45, wherein the patient suffers from hyperlipidemia.
48. The method of claim 34, wherein said patient is suffering from hyperlipidemia.
49. The method of claim 34, wherein said patient is not also administered a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
50. The method of claim 34, wherein said patient has received percutaneous transluminal coronary angioplasty (PTCA);
said patient is suffering from hyperlipidemia; and
the patient is not administered a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.