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1. (US20060051876) System and apparatus for sequential processing of analytes

Office : United States of America
Application Number: 11207443 Application Date: 18.08.2005
Publication Number: 20060051876 Publication Date: 09.03.2006
Grant Number: 7282370 Grant Date: 16.10.2007
Publication Kind : B2
Prior PCT appl.: Application Number:US98011224 ; Publication Number: Click to see the data
IPC:
G01N 21/76
G01N 21/00
G01N 37/00
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
75
Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
76
Chemiluminescence; Bioluminescence
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
37
Details not covered by any other group of this subclass
CPC:
G01N 21/253
B01J 2219/00274
B01L 3/5027
B01L 3/502715
B01L 3/502761
B01L 2200/0647
B01L 2200/10
B01L 2300/0877
B01L 2400/0403
B01L 2400/0475
B01L 2400/0622
B01L 2400/0644
G01N 2015/144
G01N 2015/1452
G01N 2035/00158
Y10S 435/81
Y10T 436/13
Y10T 436/143333
Applicants: Solexa, Inc.
Inventors: Bridgham John
Corcoran Kevin
Golda George
Pallas Michael C.
Brenner Sydney
Agents: Gorthey LeeAnn
Perkins Coie LLP
Priority Data: 08862610 23.05.1997 US
09424028 16.11.1999 US
09908131 17.07.2001 US
US98011224 22.05.1998 WO
Title: (EN) System and apparatus for sequential processing of analytes
Abstract: front page image
(EN)

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.


Also published as:
EP0985142US6406848US20020137052US20030224419US6969488JP2002507280
CA2291180AU1998077155AU2001083651WO/1998/053300