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1. (US6969488) System and apparatus for sequential processing of analytes

Office : United States of America
Application Number: 09908131 Application Date: 17.07.2001
Publication Number: 6969488 Publication Date: 29.11.2005
Grant Number: 6969488 Grant Date: 29.11.2005
Publication Kind : B2
Prior PCT appl.: Application Number:US98011224 ; Publication Number: Click to see the data
IPC:
G01N 33/48
B01L 3/00
G01N 15/14
G01N 21/25
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10
Investigating individual particles
14
Electro-optical investigation
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
17
Systems in which incident light is modified in accordance with the properties of the material investigated
25
Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
CPC:
G01N 21/253
B01J 2219/00274
B01L 3/5027
B01L 3/502715
B01L 3/502761
B01L 2200/0647
B01L 2200/10
B01L 2300/0877
B01L 2400/0403
B01L 2400/0475
B01L 2400/0622
B01L 2400/0644
G01N 2015/144
G01N 2015/1452
G01N 2035/00158
Y10S 435/81
Y10T 436/13
Y10T 436/143333
Applicants: Solexa, Inc.
Inventors: Bridgham John
Corcoran Kevin
Golda George
Brenner Sydney
Pallas Michael C.
Agents: Powers Vincent M.
Gorthey Lee Ann
Perkins Coie LLP
Priority Data: 09424028 16.11.1999 US
US98011224 22.05.1998 WO
Title: (EN) System and apparatus for sequential processing of analytes
Abstract: front page image
(EN)

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.


Also published as:
EP0985142US6406848US20020137052US20030224419US20060051876JP2002507280
CA2291180AU1998077155AU2001083651WO/1998/053300