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1. US6437177 - α-hydroxy, -amino, and halo derivatives of β-sulfonyl hydroxamic acids as matrix metallopropteinases inhibitors

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United States of America
Application Number 09196190
Application Date 20.11.1998
Publication Number 6437177
Publication Date 20.08.2002
Grant Number 6437177
Grant Date 20.08.2002
Publication Kind B1
IPC
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
C07C 317/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
02having sulfone or sulfoxide groups bound to acyclic carbon atoms
04of an acyclic saturated carbon skeleton
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
C07C 317/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
C07C 317/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
44having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
46the carbon skeleton being further substituted by singly-bound oxygen atoms
C07C 317/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
44having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
48the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
50at least one of the nitrogen atoms being part of any of the groups X being a hetero atom, Y being any atom
CPC
C07C 317/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
44having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
46the carbon skeleton being further substituted by singly-bound oxygen atoms
C07C 317/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
44having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
48the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
50at least one of the nitrogen atoms being part of any of the groups , X being a hetero atom, Y being any atom
C07C 2601/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
06with a five-membered ring
08the ring being saturated
Applicants WARPEHOSKI MARTHA A.
MITCHELL MARK ALLEN
HARPER DONALD E.
MAGGIORA LINDA LOUISE
Inventors Warpehoski, Martha A.
Mitchell, Mark Allen
Harper, Donald E.
Maggiora, Linda Louise
Agents Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Priority Data 09196190 20.11.1998 US
60072655 21.11.1997 US
Title
(EN) α-hydroxy, -amino, and halo derivatives of β-sulfonyl hydroxamic acids as matrix metallopropteinases inhibitors
Abstract
(EN)

The present invention provides a compound of formula I

or pharmaceutical acceptable salts thereof wherein R1is C4-12alkyl, C4-12alkenyl, C4-12alkynyl, —(CH2)h—C3-8cycloalkyl, substituted and unsubstituted —(CH2)h-aryl, substituted and unsubstituted —(CH2)h-het, R2is substituted and unsubstituted C1-12alkyl, substituted and unsubstituted C2-12alkenyl, substituted and unsubstituted C2-12alkynyl, substituted and unsubstituted —(CH2)h—C3-8cycloalkyl, substituted and unsubstituted —(CH2)h—C3-8cycloalkenyl, substituted and unsubstituted —(CH2)h-aryl, substituted and unsubstituted —(CH2)h-heterocyclic ring, substituted and unsubstituted —(CH2)i—X—R4(X is —O—, —S(═O)j—, —NR7—, —S(═O)2NR8—, or —C(═O)—), and —(CH2)iCHR5R6.

The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
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