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The present invention provides a compound of formula I
or pharmaceutical acceptable salts thereof wherein R1is C4-12alkyl, C4-12alkenyl, C4-12alkynyl, —(CH2)h—C3-8cycloalkyl, substituted and unsubstituted —(CH2)h-aryl, substituted and unsubstituted —(CH2)h-het, R2is substituted and unsubstituted C1-12alkyl, substituted and unsubstituted C2-12alkenyl, substituted and unsubstituted C2-12alkynyl, substituted and unsubstituted —(CH2)h—C3-8cycloalkyl, substituted and unsubstituted —(CH2)h—C3-8cycloalkenyl, substituted and unsubstituted —(CH2)h-aryl, substituted and unsubstituted —(CH2)h-heterocyclic ring, substituted and unsubstituted —(CH2)i—X—R4(X is —O—, —S(═O)j—, —NR7—, —S(═O)2NR8—, or —C(═O)—), and —(CH2)iCHR5R6.
The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.