Processing

Please wait...

Settings

Settings

Goto Application

1. US6217850 - Method of making lyophilized microbubble compositions useful as contrast agents

Office United States of America
Application Number 09084105
Application Date 26.05.1998
Publication Number 6217850
Publication Date 17.04.2001
Grant Number 6217850
Grant Date 17.04.2001
Publication Kind B1
IPC
B01F 17/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
17Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
A61B 8/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
A61K 49/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
B01J 13/02
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
B32B 15/02
BPERFORMING OPERATIONS; TRANSPORTING
32LAYERED PRODUCTS
BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
15Layered products essentially comprising metal
02in a form other than a sheet, e.g. wire, particles
CPC
A61K 49/223
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
A61K 49/227
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
227Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
Y10T 428/2982
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
428Stock material or miscellaneous articles
29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
2982Particulate matter [e.g., sphere, flake, etc.]
Applicants Nycomed Imaging AS
Inventors Dugstad, Harald
Klaveness, Jo
Rongved, Pål
Skurtveit, Roald
Braenden, Jorunn
Agents Bacon & Thomas
Priority Data 9511488 07.06.1995 GB
9603466 19.02.1996 GB
Title
(EN) Method of making lyophilized microbubble compositions useful as contrast agents
Abstract
(EN)

Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful both as efficacious contrast agents per se and as intermediates in the preparation of contrast agents wherein the phospholipids are crosslinked or polymerised. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.