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1. (US5334703) Chromogenic substrate

Office : United States of America
Application Number: 07859717 Application Date: 11.06.1992
Publication Number: 5334703 Publication Date: 02.08.1994
Grant Number: 5334703 Grant Date: 02.08.1994
Publication Kind : A
Prior PCT appl.: Application Number:SE90000797 ; Publication Number: Click to see the data
IPC:
C07K 5/10
C07K 5/00
C07K 1/02
C07K 1/00
C07K 1/113
C07K 5/08
C07K 5/083
C07K 5/093
C07K 5/103
C07K 11/00
C12Q 1/37
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
02
in solution
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
107
by chemical modification of precursor peptides
113
without change of the primary structure
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
08
Tripeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
08
Tripeptides
083
the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
08
Tripeptides
093
the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
103
the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
11
Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
37
involving peptidase or proteinase
Applicants: Chromonogenix AB
Inventors: Arielly Salo
Agents: Pollock, Vande Sande & Priddy
Priority Data: 8904188 12.12.1989 SE
Title: (EN) Chromogenic substrate
Abstract: front page image
(EN)

The invention relates to, novel peptide derivatives with the formula: R.sub.1 -A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 -R.sub.2 or its salt, wherein R.sub.1 =H or a protective group, A.sub.1 =H, Ile, Leu or Val, A.sub.2 =Glu, Asp, Ser, Thr; A.sub.3 =Gly or Glyc; A.sub.4 =Arg or Lys; R.sub.2 =4-nitroaniline with the proviso that A.sub.3 is Gly when A.sub.4 is Lys and that A.sub.3 is Glyc when A.sub.4 is Arg. The invention also discloses the process for the preparation of the peptide derivatives, the method for the determination of the bacterial endotoxins by the use of the invented peptide derivatives and the use of these derivatives for determination of bacterial endotoxins.


Also published as:
ES2098344EP0505428JPH05506209DE000069030102AU1991069579WO/1991/009052