US20230002475 INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

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United States of America

Application Number 17931596

Application Date 13.09.2022

Publication Number 20230002475

Publication Date 05.01.2023

Publication Kind A1

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Applicants XYPHOS BIOSCIENCES INC.

Inventors Kyle LANDGRAF
Daniel P. Steiger
Steven R. Williams
David W. Martin, JR.

Title

(EN) INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

Abstract

(EN)

This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
705	Receptors; Cell surface antigens; Cell surface determinants
74	Major histocompatibility complex (MHC)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
32	against translation products from oncogenes

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
39	characterised by the immunostimulating additives, e.g. chemical adjuvants

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40	against enzymes

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1. US20230002475 - INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
90	characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
92	Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
90	characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
94	Stability, e.g. half-life, pH, temperature or enzyme-resistance

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2318	Antibody mimetics or scaffolds
20	Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
60	characterized by non-natural combinations of immunoglobulin fragments
62	comprising only variable region components
622	Single chain antibody (scFv)