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A software architecture and system for delivering selected sanitation protocols for multiple pathogens and pests for sanitizing a physical space. The software architecture and system generally includes a plurality of protocol identifiers linked to sanitation protocols arranged as pages in a protocol storage. Each sanitation protocol comprises a plurality of parameters arranged in tabular form for carrying out a sanitation process for one or more pathogens and/or pests. Also included are a control panel/display, controller, heat source, UV light source, and sensors. The protocol identifiers are displayed on the control panel/display and the controller retrieves the parameters of a selected sanitation protocol from the protocol storage. The controller operates in a closed-loop control arrangement with the heat source, UV light source, and sensors to automatically carry out a sanitation process according to the parameters of the selected sanitation protocol.