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Method for estimating measurable properties in a three-dimensional volume of material, in particular, the present method providing for the estimation of physical, chemical, biological and/or statistical properties of a volume of material, be it solid, liquid or gaseous; wherein a two-dimensional digital image is obtained, representing a single projection of said volume, which is obtained from a single view position in transmissive or partially reflective mode and wherein said two-dimensional digital image is subjected to analysis by means of machine learning algorithms in supervised mode.