Processing

Please wait...

Settings

Settings

Goto Application

1. US20200054358 - CAUSING ISCHEMIA IN TUMORS

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

Claims

1. A method for treating a tumor that is at least partially within an organ of a body of a subject, the method comprising:
passing a tension member within the organ between an entry opening and an exit opening, each opening being at a surface of the organ, and in close fit around a predetermined volumetric region that encompasses at least a portion of the tumor;
tightening the tension member to cause compression of the volumetric region, thereby directly increasing a pressure within the tumor; and
maintaining the increased pressure such that most or all tissues of the tumor undergo ischemic resulting directly from the compression caused by the tightened tension member.
2. The method according to claim 1, wherein the passing includes winding the tension member and/or a plurality of additional tension members along separate paths around the volumetric region.
3. The method according to claim 2, wherein the tightening includes tightening at least one of the tension member and/or the plurality of additional tension members to cause volumetric compression of the volumetric region.
4. The method according to claim 1, wherein the volumetric region encompasses a majority or entirety of a volume of the tumor.
5. The method according to claim 1, wherein the compression is maintained continuously at least until achieving necrosis in substantially all tissues of the tumor.
6. The method according to claim 1, wherein the compression is maintained continuously for a period of no less than 1 hour.
7. The method according to claim 1, wherein the tightening the tension member increases the pressure within the tumor to a first level and injures tissue within the volumetric region, the method further comprising:
maintaining the tension member in a tightened state while tissue within the volumetric region that has been injured swells in response to the injury, wherein swelling of the tissue within the volumetric region increases the pressure within the tumor to a second level that exceeds the first level.
8. The method according to claim 1, further comprising passing the tension member along a predetermined passage line between the entry opening and the exit opening.
9. The method according to claim 8, wherein the passage line projects across one or more blood vessels feeding the tumor, such that the tightening of the tension member directly causes occlusion of the one or more blood vessels.
10. The method according to claim 1, wherein at least a portion of the tumor is situated intramurally within the organ, and wherein passing the tension member within the organ comprises passing the tension member through an intramural portion of the organ.
11. The method according to claim 1, wherein the tumor is a uterine fibroid.
12. The method according to claim 1, further comprising creating a surgical access to the organ from outside the body, wherein at least one of the passing, tightening, and maintaining is performed via the surgical access.
13. The method according to claim 12, further comprising closing the surgical access while the tension member and the fastener remain within the body of the subject.
14. The method according to claim 1, wherein the tightening includes or is followed by securing a first portion of the tension member protruding from the entry opening to a second portion of the tension member protruding from the exit opening, wherein the securing facilitates the maintaining.
15. The method according to claim 14, wherein the securing is performed outside boundaries of the organ.
16. The method according to claim 14, wherein the securing comprises attaching a fastener to the tension member.
17. The method according to claim 16, wherein the securing comprises crimping the fastener to securely grasp the tension member.
18. The method according to claim 1, wherein passing the tension member comprises advancing an end of the tension member through the exit opening, around the tumor, and through the entry opening such that a first portion of the tension member protrudes from the organ through the exit opening and a second portion of the tension member protrudes from the organ through the entry opening.
19. The method according to claim 18, further comprising:
advancing an elongated member through the entry opening, around the tumor, and through the exit opening; and
coupling the elongated member to the tension member prior to the passing the tension member,
wherein the passing the tension member comprises withdrawing the elongated member through the exit opening, around the tumor, and through the entry opening while coupled to the tension member.
20. The method according to claim 1, further comprising:
forming a passage around the volumetric region between the entry and exit openings, wherein the passing is performed after the forming and mostly or entirely within the passage and includes pulling the tension member towards the entry opening.
21. The method according to claim 1, wherein the entry opening is located at a first location on or adjacent to the tumor and the exit opening is located at a second location on or adjacent to the tumor spaced from the first location, such that the tumor is located between the entry and exit openings.
22. The method according to claim 1, wherein the tension member comprises a suture wire.
23. The method according to claim 2, wherein the tightening comprises tightening the tension member and/or the plurality of additional tension members to collectively apply compressive force toward an interior of the tumor.
24. The method according to claim 1, wherein the tightening comprises tightening the tension member to achieve a chosen tensioning force.
25. The method according to claim 1, further comprising measuring a tensioning force applied to the tension member, and/or measuring the pressure within the tumor, during the tightening.
26. A method for treating a tumor within a body of a subject, the method comprising:
deploying a plurality of windings of at least one tension member around the tumor, at least a portion of each of the windings being spaced apart from a portion of each adjacent winding;
tightening the at least one tension member such that the plurality of windings collectively causes volumetric compression of the tumor; and
maintaining the volumetric compression continuously to achieve ischemia in most or all tissues of the tumor.
27. A method according to claim 26, wherein the tightening comprises tightening the at least one tension member to achieve a chosen tension force within the tumor and/or to achieve a chosen pressure within the tumor.
28. The method according to claim 26, wherein the tightening comprises tightening the at least one tension member such that each of the plurality of windings applies compressive force toward an interior of the tumor.
29. A method comprising:
volumetrically compressing a tumor within a patient to increase a pressure within the tumor above a threshold level that is sufficient to cause ischemia of the tumor; and
maintaining the pressure above the threshold level for a period sufficient to permit at least a portion of the tumor to necrotize due to the ischemia.
30. The method of claim 29, further comprising circumscribing the tumor with at least one device of foreign origin relative to the patient, wherein the volumetrically compressing the tumor and maintaining the pressure above the threshold level are achieved via the at least one device.
31. The method of claim 30, wherein volumetrically compressing the tumor comprises reducing a profile of the device around the tumor.
32. The method of claim 29, wherein the volumetrically compressing comprises compressing the tumor along at least first and second lines of compression that extend around an outer surface of the tumor along different paths.
33. The method of claim 29, further comprising encompassing the tumor with at least one tension member to define a three-dimensional shape around the tumor, wherein the volumetrically compressing the tumor comprises decreasing a size of the three-dimensional shape.
34. The method of claim 33, wherein decreasing the size of the three-dimensional shape is achieved by tightening the at least one tension member.
35. The method of claim 29, wherein the threshold level of the pressure is no less than 20 mmHg.