US20190092737 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof

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United States of America

Application Number 15528589

Application Date 20.11.2015

Publication Number 20190092737

Publication Date 28.03.2019

Grant Number 11117877

Grant Date 14.09.2021

Publication Kind B2

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Applicants BSIM Therapeutics, S.A.

Inventors Rui Manuel Pontes Meireles Ferreira de Brito
Carlos José Vieira Simões
Teresa Margarida Vasconcelos Dias de Pinho e Melo
Bruno Lourenço da Silva Victor
Zaida Catarina Lourenço de Almeida
Ana Lúcia Cabral Cardoso Lopes
Bruno Filipe Oliveira Nascimento

Agents Wolf, Greenfield & Sacks, P.C.

Title

(EN) 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof

Abstract

(EN)

Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
277	Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02	not condensed with other rings
20	having two or three double bonds between ring members or between ring members and non-ring members
32	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36	Sulfur atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425	Thiazoles
426	1,3-Thiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45	Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06	Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
277	Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02	not condensed with other rings
20	having two or three double bonds between ring members or between ring members and non-ring members
32	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34	Oxygen atoms

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1. US20190092737 - 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof