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1. (US20180344857) ANALGESIC PREPARATION WITH NANOCARRIERS AND USE THEREOF

Office : United States of America
Application Number: 15780954 Application Date: 08.12.2016
Publication Number: 20180344857 Publication Date: 06.12.2018
Publication Kind : A1
Prior PCT appl.: Application Number:PCTDE2016100569 ; Publication Number: Click to see the data
IPC:
A61K 47/34
A61K 47/10
A61K 9/51
A61P 25/04
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
CPC:
A61K 2300/00
A61K 31/485
A61K 47/10
A61K 47/34
A61K 9/5146
A61P 25/04
Applicants: DendroPharm GmbH
Inventors: Emanuel Fleige
Sam Moré
Michael Unbehauen
Rainer Haag
Christoph Stein
Halina Machelska-Stein
Florian Paulus
Priority Data: 10 2015 121 366.4 08.12.2015 DE
Title: (EN) ANALGESIC PREPARATION WITH NANOCARRIERS AND USE THEREOF
Abstract: front page image
(EN)

The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.


Also published as:
EP3386501WO/2017/097291