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Application Id/Number

1. US20180194797 - Oxysterols and methods of use thereof

National Biblio. Data
Description
Claims
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- WIPO Translate

Office

United States of America

Application Number 15742424

Application Date 06.07.2016

Publication Number 20180194797

Publication Date 12.07.2018

Grant Number 11117924

Grant Date 14.09.2021

Publication Kind B2

IPC

C07J 9/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
9	Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

A61P 23/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23	Anaesthetics

A61P 25/20

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
20	Hypnotics; Sedatives

A61P 3/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3	Drugs for disorders of the metabolism

C07J 17/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
17	Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopentahydrophenanthrene skeleton

C07J 31/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
31	Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

View more classifications

C07J 9/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
9	Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

A61P 23/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23	Anaesthetics

A61P 25/20

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
20	Hypnotics; Sedatives

A61P 3/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3	Drugs for disorders of the metabolism

C07J 17/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
17	Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopentahydrophenanthrene skeleton

C07J 31/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
31	Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

C07J 7/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
7	Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms

C07J 13/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
13	Normal steroids containing carbon, hydrogen, halogen, or oxygen, having a carbon-to-carbon double bond from or to position 17

C07J 41/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
41	Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

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CPC

A61P 3/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3	Drugs for disorders of the metabolism

C07J 9/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
9	Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

A61P 23/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23	Anaesthetics

A61P 25/20

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
20	Hypnotics; Sedatives

C07J 17/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
17	Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

C07J 7/002

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
7	Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
0005	not substituted in position 21
001	substituted in position 20 by a keto group
0015	not substituted in position 17 alfa
002	not substituted in position 16

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A61P 3/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3	Drugs for disorders of the metabolism

C07J 9/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
9	Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

A61P 23/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23	Anaesthetics

A61P 25/20

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
20	Hypnotics; Sedatives

C07J 17/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
17	Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

C07J 7/002

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
7	Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
0005	not substituted in position 21
001	substituted in position 20 by a keto group
0015	not substituted in position 17 alfa
002	not substituted in position 16

C07J 9/005

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
9	Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
005	containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

C07J 13/005

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
13	Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
005	with double bond in position 16 (17)

C07J 13/007

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
13	Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
007	with double bond in position 17 (20)

C07J 31/006

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
31	Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
006	not covered by C07J31/003

C07J 41/0061

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
41	Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0033	not covered by C07J41/0005
0055	the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
0061	one of the carbon atoms being part of an amide group

View less classifications

Applicants Sage Therapeutics, Inc.

Inventors Francesco G. Salituro
Albert Jean Robichaud
Gabriel Martinez Botella
Boyd L. Harrison

Agents Haley Guiliano LLP

Title

(EN) Oxysterols and methods of use thereof

Abstract

(EN)

Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R¹, R², and R³are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

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1. US20180194797 - Oxysterols and methods of use thereof