SEQ ID NO: 1 |
Human NBCn1 DNA sequence variant a cloned from |
breast cancer tissue. The underlined 5′-region |
indicates a region, which differs from SEG ID |
NO: 2. |
atggaaagatttcgtctggagaagaagttacctggtcctgatgaagaag |
ctgttgtggatcttggcaaaactagctcaactgtgaacaccaagtttga |
aaaagaagaactagaaagtcatagagctgtatatattggtgttcacgtc |
ccgtttagtaaagagagtcgtcggcgtcataggcatcgcggacacaaac |
atcaccaccggagaagaaaagataaagaatcagataaagaagatggacg |
ggaatctccttcttatgatacaccatcccagagagttcagtttatcctt |
ggtactgaagatgatgatgaagaacatattccccatgatctcttcacgg |
aaatggatgaactgtgttacagagatggagaagaatatgaatggaaaga |
aactgctagatggctgaaatttgaagaggatgttgaagatggcggtgac |
cgatggagtaaaccttatgtggcaactctctctttgcacagtctttttg |
aactaaggagttgcatcctcaatggaacagtcatgctggatatgagagc |
aagcactctagatgaaatagcagatatggtattagacaacatgatagct |
tctggccaattagacgagtccatacgagagaatgtcagagaagctcttc |
tgaagagacatcatcatcagaatgagaaaagattcaccagtcggattcc |
tcttgttcgatcttttgcagatataggcaagaaacattctgaccctcac |
ttgcttgaaaggaatggtattttggcctctccccagtctgctcctggaa |
acttggacaatagtaaaagtggagaaattaaaggtaatggaagtggtgg |
aagcagagaaaatagtactgttgacttcagcaaggttgatatgaatttc |
atgagaaaaattcctacgggtgctgaggcatccaacgtcctggtgggcg |
aagtagactttttggaaaggccaataattgcatttgtgagactggctcc |
tgctgtcctccttacagggttgactgaggtccctgttccaaccaggttt |
ttgtttttgttattgggtccagcgggcaaggcaccacagtaccatgaaa |
ttggacgatcaatagccactctcatgacagatgagattttccatgatgt |
agcttataaagcaaaagacagaaatgacctcttatctggaattgatgaa |
tttttagatcaagtaactgtcctacctccaggagagtgggatccttcta |
tacgcatagaaccaccaaaaagtgtcccttctcaggaaaagagaaagat |
tcctgtgtttcacaatggatctacccccacactgggtgagactcctaaa |
gaggccgctcatcatgctgggcctgagctacagaggactggacggcttt |
ttggtggtttgatacttgacatcaaaaggaaagcaccttttttcttgag |
tgacttcaaggatgcattaagcctgcagtgcctggcctcgattcttttc |
ctatactgtgcctgtatgtctcctgtaatcacttttggagggctgcttg |
gagaagctacagaaggcagaataagtgcaatagagtctctttttggagc |
atcattaactgggattgcctattcattgtttgctgggcaacctctaaca |
atattggggagcacaggtccagttctagtgtttgaaaaaattttatata |
aattctgcagagattatcaactttcttatctgtctttaagaaccagtat |
tggtctgtggacttcttttttgtgcattgttttggttgcaacagatgca |
agcagccttgtgtgttatattactcgatttacagaagaggcttttgcag |
cccttatttgcatcatattcatctacgaggctttggagaagctctttga |
tttaggagaaacatatgcatttaatatgcacaacaacttagataaactg |
accagctactcatgtgtatgtactgaacctccaaaccccagcaatgaaa |
ctctagcacaatggaagaaagataatataacagcacacaatatttcctg |
gagaaatcttactgtttctgaatgtaaaaaacttcgtggtgtattcttg |
gggtcagcttgtggtcatcatggaccttatattccagatgtgctctttt |
ggtgtgtcatcttgtttttcacaacattttttctgtcttcattcctcaa |
gcaatttaagaccaagcgttactttcctaccaaggtgcgatcgacaatc |
agtgattttgctgtatttctcacaatagtaataatggttacaattgact |
accttgtaggagttccatctcctaaacttcatgttcctgaaaaatttga |
gcctactcatccagagagagggtggatcataagcccactgggagataat |
ccttggtggaccttattaatagctgctattcctgctttgctttgtacca |
ttctcatctttatggatcaacaaatcacagctgtaattataaacagaaa |
ggaacacaaattgaagaaaggagctggctatcaccttgatttgctcatg |
gttggcgttatgttgggagtttgctctgtcatgggacttccatggtttg |
tggctgcaacagtgttgtcaataagtcatgtcaacagcttaaaagttga |
atctgaatgttctgctccaggggaacaacccaagtttttgggaattcgt |
gaacagcgggttacagggctaatgatttttattctaatgggcctctctg |
tgttcatgacttcagtcctaaagtttattccaatgcctgttctgtatgg |
tgttttcctttatatgggagtttcctcattaaaaggaatccagttattt |
gaccgtataaaattatttggaatgcctgctaagcatcagcctgatttga |
tatacctccgttatgtgccgctctggaaggtccatattttcacagtcat |
tcagcttacttgtttggtccttttatgggtgataaaagtttcagctgct |
gcagtggtttttcccatgatggttcttgcattagtgtttgtgcgcaaac |
tcatggacctgtgtttcacgaagagagaacttagttggcttgatgatct |
tatgccagaaagtaagaaaaagaaagaagatgacaaaaagaaaaaagag |
aaagaggaagctgaacggatgcttcaagatgatgatgatactgtgcacc |
ttccatttgaagggggaagtctcttgcaaattccagtcaaggccctaaa |
atatagtcctgataaacctgtgagtgtgaaaataagttttgaagatgaa |
ccaagaaagaaatacgtggatgctgaaacttcattatagaattgaacca |
agaggcattatacatatagatatatacatatgtaatgtgtgcgtatcat |
gtcactatatataagaatattgtatgtcatgctgtttatgtgtgactac |
cgggtttttaaaagtagt |
|
SEQ ID NO: 2 |
Human NBCn1 DNA sequence variant b cloned from |
breast cancer tissue. The underlined 5′-region |
indicates a region, which differs from SEG ID |
NO: 1. |
atggaggctgatggggccggcgagcagatgagaccgctactcacccggg |
gtcctgatgaagaagctgttgtggatcttggcaaaactagctcaactgt |
gaacaccaagtttgaaaaagaagaactagaaagtcatagagctgtatat |
attggtgttcacgtcccgtttagtaaagagagtcgtcggcgtcataggc |
atcgcggacacaaacatcaccaccggagaagaaaagataaagaatcaga |
taaagaagatggacgggaatctccttcttatgatacaccatcccagaga |
gttcagtttatccttggtactgaagatgatgatgaagaacatattcccc |
atgatctcttcacggaaatggatgaactgtgttacagagatggagaaga |
atatgaatggaaagaaactgctagatggctgaaatttgaagaggatgtt |
gaagatggcggtgaccgatggagtaaaccttatgtggcaactctctctt |
tgcacagtctttttgaactaaggagttgcatcctcaatggaacagtcat |
gctggatatgagagcaagcactctagatgaaatagcagatatggtatta |
gacaacatgatagcttctggccaattagacgagtccatacgagagaatg |
tcagagaagctcttctgaagagacatcatcatcagaatgagaaaagatt |
caccagtcggattcctcttgttcgatcttttgcagatataggcaagaaa |
cattctgaccctcacttgcttgaaaggaatggtattttggcctctcccc |
agtctgctcctggaaacttggacaatagtaaaagtggagaaattaaagg |
taatggaagtggtggaagcagagaaaatagtactgttgacttcagcaag |
gttgatatgaatttcatgagaaaaattcctacgggtgctgaggcatcca |
acgtcctggtgggcgaagtagactttttggaaaggccaataattgcatt |
tgtgagactggctcctgctgtcctccttacagggttgactgaggtccct |
gttccaaccaggthttgtttttgttattgggtccagcgggcaaggcacc |
acagtaccatgaaattggacgatcaatagccactctcatgacagatgag |
attttccatgatgtagcttataaagcaaaagacagaaatgacctcttat |
ctggaattgatgaatttttagatcaagtaactgtcctacctccaggaga |
gtgggatccttctatacgcatagaaccaccaaaaagtgtcccttctcag |
gaaaagagaaagattcctgtgtttcacaatggatctacccccacactgg |
gtgagactcctaaagaggccgctcatcatgctgggcctgagctacagag |
gactggacggctttttggtggtttgatacttgacatcaaaaggaaagca |
ccttttttcttgagtgacttcaaggatgcattaagcctgcagtgcctgg |
cctcgattcttttcctatactgtgcctgtatgtctcctgtaatcacttt |
tggagggctgcttggagaagctacagaaggcagaataagtgcaatagag |
tctctttttggagcatcattaactgggattgcctattcattgtttgctg |
ggcaacctctaacaatattggggagcacaggtccagttctagtgtttga |
aaaaattttatataaattctgcagagattatcaactttcttatctgtct |
ttaagaaccagtattggtctgtggacttcttttttgtgcattgttttgg |
ttgcaacagatgcaagcagccttgtgtgttatattactcgatttacaga |
agaggcttttgcagcccttatttgcatcatattcatctacgaggctttg |
gagaagctctttgatttaggagaaacatatgcatttaatatgcacaaca |
acttagataaactgaccagctactcatgtgtatgtactgaacctccaaa |
ccccagcaatgaaactctagcacaatggaagaaagataatataacagca |
cacaatatttcctggagaaatcttactgtttctgaatgtaaaaaacttc |
gtggtgtattcttggggtcagcttgtggtcatcatggaccttatattcc |
agatgtgctcttttggtgtgtcatcttgtttttcacaacattttttctg |
tcttcattcctcaagcaatttaagaccaagcgttactttcctaccaagg |
tgcgatcgacaatcagtgattttgctgtatttctcacaatagtaataat |
ggttacaattgactaccttgtaggagttccatctcctaaacttcatgtt |
cctgaaaaatttgagcctactcatccagagagagggtggatcataagcc |
cactgggagataatccttggtggaccttattaatagctgctattcctgc |
tttgctttgtaccattctcatctttatggatcaacaaatcacagctgta |
attataaacagaaaggaacacaaattgaagaaaggagctggctatcacc |
ttgatttgctcatggttggcgttatgttgggagtttgctctgtcatggg |
acttccatggtttgtggctgcaacagtgttgtcaataagtcatgtcaac |
agcttaaaagttgaatctgaatgttctgctccaggggaacaacccaagt |
ttttgggaattcgtgaacagcgggttacagggctaatgatttttattct |
aatgggcctctctgtgttcatgacttcagtcctaaagtttattccaatg |
cctgttctgtatggtgttttcctttatatgggagtttcctcattaaaag |
gaatccagttatttgaccgtataaaattatttggaatgcctgctaagca |
tcagcctgatttgatatacctccgttatgtgccgctctggaaggtccat |
attttcacagtcattcagcttacttgtttggtccttttatgggtgataa |
aagtttcagctgctgcagtggtttttcccatgatggttcttgcattagt |
gtttgtgcgcaaactcatggacctgtgthcacgaagagagaacttagtt |
ggcttgatgatcttatgccagaaagtaagaaaaagaaagaagatgacaa |
aaagaaaaaagagaaagaggaagctgaacggatgcttcaagatgatgat |
gatactgtgcaccttccatttgaagggggaagtctcttgcaaattccag |
tcaaggccctaaaatatagtgttgatccctcaattgttaacatatcaga |
tgaaatggccaaaactgcacagtggaaggcactttccatgaatactgag |
aatgccaaagtaaccagatctaacatgagtcctgataaacctgtgagtg |
tgaaaataagttttgaagatgaaccaagaaagaaatacgtggatgctga |
aacttcattatagaattgaaccaagaggcattatacatatagatatata |
catatgtaatgtgtgcgtatcatgtcactatatataagaatattgtatg |
tcatgctgtttatgtgtgactaccgggtttttaaaagtagtgtctggag |
tttgtaatgagcaccgtggagactatgtatttaatgaaatgctctcttt |
gaagtgaggtacatggttctt |
|
SEQ ID NO: 3 |
Human NBCn1 Peptide sequence (variant a) cloned |
from breast cancer tissue. The underlined N- |
terminal region indicates where SEG ID NO: 3 |
differ from SEG ID NO: 4. |
MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHV |
PFSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFIL |
GTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGD |
RWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIA |
SGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPH |
LLERNGILASPQSAPGNLDNSKSGElKGNGSGGSRENSTVDFSKVDMNF |
MRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRF |
LFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDE |
FLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPK |
EAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILF |
LYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLT |
ILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLVVTSFLCIVLVATD |
ASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDK |
LTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVF |
LGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRST |
ISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGD |
NPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLL |
MVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGI |
REQRVTGLMIFlLMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQL |
FDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSA |
AAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKK |
EKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFED |
EPRKKYVDAETSL* |
|
SEQ ID NO: 4 |
Human NBCn1 Peptide sequence (variant b) cloned |
from breast cancer tissue. The underlined N- |
terminal region indicates where SEG ID NO: 3 |
differ from SEG ID NO: 4. |
MEADGAGEQMRPLLTRGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVY |
IGVHVPFSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQR |
VQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDV |
EDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVL |
DNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKK |
HSDPHLLERNGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSK |
VDMNFMRKIPTGAEASNVLVGEVDFLERPIAFVRLAPAVLLTGLTEVPV |
PTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLS |
GIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLG |
ETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLA |
SILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAG |
QPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLVVTSFLCIVL |
VATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHN |
NLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKL |
RGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTK |
VRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIIS |
PLGDNPWWTLLIAAIPALLCTILIFDQQITAVIINRKEHKLKKGAGYHL |
DLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKF |
LGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKG |
IQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIK |
VSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDK |
KKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSVDPSIVNISD |
EMAKTAQWKALSMNTENAKVTRSNMSPDKPVSVKISFEDEPRKKYVDAE |
TSL* |
|
SEQ ID NO: 5 |
EL2, human and mouse: |
SPVITFGGLLGEATEGRISAIESLFGASLT |
|
SEQ ID NO: 6 |
EL3, human: |
KLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAH |
NISWRNLTVSECKKLRGVFLGSACGHHGP |
|
SEQ ID NO: 7 |
EL3, mouse: |
Unformatted residues are fully conserved, bold |
strongly conserved, italicized weakly conserved, |
and underlined without consensus between the mouse |
and human sequence. |
KLFHLGEIYAFNMHNNLDELTSYTCVCAEPSNPSNETLELWKRKNITAYS |
VSWGNLTVSECKTFHGMFVGSACGPHGP |
|
SEQ ID NO: 8 |
EL4, human: PSPKLHVPEKFEPTHPERGWIISPLGDNPW |
|
SEQ ID NO: 9 |
EL4, mouse: PSPKLHVPEKFEPTDPSRGWIISPLGDNPW |
|
SEQ ID NO: 10 |
EL5, human and mouse: |
SISHVNSLKVESECSAPGEQPKFLGIREQR |
|
SEQ ID NO: 11 |
human |
MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVP |
FSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGT |
EDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWS |
KPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQL |
DESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERN |
GEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCT |
TPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHP |
PEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGS |
GGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLA |
PAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDV |
AYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIP |
VFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF |
KDALSLQC |
|
SEQ ID NO: 12 |
human |
ATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVT |
|
SEQ ID NO: 13 |
human |
DRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTC |
|
SEQ ID NO: 14 |
NBCn1_EL3h1.1: |
[Hz]-HNNLDKLTSYSCVCTEPPNPSNETLAQWKKDNITA-amide |
(SEQ ID NO: 14) |
|
SEQ ID NO: 15 |
NBCn1_EL3h2.1: |
[Hz]-LAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSA-amide |
(SEQ ID NO: 15). |
|