Substances suitable for the (production of) nanofibres or present in the nanoscaffold may comprise one or more polyamides, polyurethanes, polyethersulphones, polyvinyl alcohol, polyvinyl butyral, polyacrylonitrile, polyethyleneoxide, polystyrene, polyvinylidene fluoride, polyvinylpyrrolidone, povidone-iodine, alginate, silk fibroin, polyacrylic acid, polyglycolic acid, polyacrylic acid, gelatine, chitosan, collagen, polyaramid, polylactic acid, poly-ε-caprolactone, hyaluronic acid and/or (supersaturated) collagen. The surface of nanofibers can be (further) physically or chemically modified, such as for the purpose of binding and release of particles, in particular macromolecular particles (e.g. proteins, DNA/RNA, polysaccharides) and/or nanoparticles or microparticles of low-molecular substances. Examples of modifications are: change in surface charge and its density, change in surface wettability rate, attachment of ligand(s) for selective binding, such as metallochelating complexes, specific ligands—biotin, monoclonal antibodies and their fragments, peptides, etc.