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1. (US20170216266) Multi-component crystals of vismodegib and selected co-crystal formers or solvents

Office : United States of America
Application Number: 15501908 Application Date: 03.08.2015
Publication Number: 20170216266 Publication Date: 03.08.2017
Grant Number: 10105355 Grant Date: 23.10.2018
Publication Kind : B2
Prior PCT appl.: Application Number:PCTEP2015067822 ; Publication Number: Click to see the data
IPC:
C07D 213/40
A61K 31/4402
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24
with substituted hydrocarbon radicals attached to ring carbon atoms
36
Radicals substituted by singly-bound nitrogen atoms
40
Acylated substituent nitrogen atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4402
only substituted in position 2, e.g. pheniramine, bisacodyl
CPC:
A61K 31/4402
C07D 213/40
Applicants: BASF SE
Inventors: Martin Viertelhaus
Tiziana Chiodo
Beate Salvador
Marcus Vossen
Andreas Hafner
Tobias Hintermann
Walter Weishaar
Rolf Hellmann
Agents: Drinker Biddle & Reath LLP
Priority Data: 14180255 07.08.2014 EP
Title: (EN) Multi-component crystals of vismodegib and selected co-crystal formers or solvents
Abstract: front page image
(EN)

The present invention primarily relates to multi-component crystals comprising a compound of formula 1

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and a second compound selected from the group consisting of co-crystal formers and solvents. The invention is further related to pharmaceutical compositions comprising such multi-component crystals. Furthermore, the invention relates to processes for preparing said multi-component crystals. The invention also relates to several aspects of using said multi-component crystals or pharmaceutical compositions to treat a disease.


Also published as:
CN106573888CA2955570JP2017524004IN201727007261WO/2016/020324