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1. (US09487784) Antisense antibacterial method and compound

Pub. No.:    09487784    International Application No.:    13680790
Publication Date: Wed Nov 09 00:59:59 CET 2016 International Filing Date: Tue Nov 20 00:59:59 CET 2012
IPC: C12N 15/113
C07F 9/6558
C07F 9/6561
Applicants: Sarepta Therapeutics, Inc.
Inventors: Bruce L. Geller
Jesse D. Deere
Patrick L. Iversen
Title: Antisense antibacterial method and compound
Abstract:

A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases and has a targeting nucleic acid sequence of no fewer than 10 bases in length that is complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication. The compound binds to a target mRNA with a Tm of between 50° to 60° C. The relatively short antisense compounds are substantially more active than conventional antisense compounds having a targeting base sequence of 15 or more bases.