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1. (US20160109467) Microfluidic devices and methods for performing serum separation and blood cross-matching

Office : United States of America
Application Number: 14889366 Application Date: 07.05.2014
Publication Number: 20160109467 Publication Date: 21.04.2016
Grant Number: 10386377 Grant Date: 20.08.2019
Publication Kind : B2
Prior PCT appl.: Application Number:PCTUS2014037192 ; Publication Number: Click to see the data
IPC:
B01L 3/00
G01N 33/80
G01N 33/49
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
80
involving blood groups or blood types
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
487
of liquid biological material
49
blood
CPC:
B01L 3/50273
G01N 33/80
B01L 3/502715
B01L 3/502723
B01L 3/502738
B01L 3/502753
G01N 33/491
B01L 2200/027
B01L 2200/10
B01L 2300/0681
B01L 2300/0816
B01L 2300/0883
B01L 2400/0406
B01L 2400/0481
Applicants: Micronics, Inc.
Inventors: Andrew W. Kolb
Carolina L. Elmufdi
C. Frederick Battrell
Agents: Seed IP Law Group LLP
Priority Data:
Title: (EN) Microfluidic devices and methods for performing serum separation and blood cross-matching
Abstract: front page image
(EN)

Microfluidic cartridges or devices for serum separation and blood cross-match analysis are provided. The devices may include a serum separation subcircuit alone or in combination with a solute mixing subcircuit. The serum separation subcircuit promotes on-cartridge clotting of a blood sample and manipulates the flow of the separated serum sample for subsequent cross-match analysis with a second blood sample, for example. The solute mixing subcircuit includes at least two intake channels, one for a whole blood sample from, for example, a blood donor and the other for the separated serum sample from, for example, a transfusion recipient. The solute mixing subcircuit further includes a serpentine mixing channel conjoined to a downstream channel. Under vacuum generated by a conjoined finger pump, the two input streams fill the serpentine mixing and downstream channels due to capillary action, enabling visualization of an agglutination reaction.


Also published as:
EP2994750WO/2014/182844