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1. US20160052881 - Chalcone derivatives having an anti-allergic activity

Office
United States of America
Application Number 14781145
Application Date 04.04.2014
Publication Number 20160052881
Publication Date 25.02.2016
Grant Number 09896415
Grant Date 20.02.2018
Publication Kind B2
IPC
C07D 211/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
30with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
32by oxygen atoms
C07D 211/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
CPC
C07D 211/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
30with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
32by oxygen atoms
C07D 211/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
Applicants UNIVERSITE CLAUDE BERNARD LYON I
HOSPICES CIVILS DE LYON
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors Charles Dumontet
Ahcene Boumendjel
Guillaume Monneret
Agents Ladas & Parry LLP
Priority Data 1353091 05.04.2013 FR
Title
(EN) Chalcone derivatives having an anti-allergic activity
Abstract
(EN)

The present invention relates to the compounds of formula (I):

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wherein:

    • R2, R4 and R6, either identical or different, represent a hydrogen, chlorine bromine, iodine or fluorine atom, or a group —OH or —O-alkyl comprising from 1 to 6 carbon atoms;
    • R2′ and R4′, either identical or different, represent a hydrogen atom, or a group —OH or —O-alkyl comprising from 1 to 6 carbon atoms; with R2′ and/or R4′ which represent a methoxy group;
    • n is equal to 1, 2, 3;
    • X═CH2, O, S or N(R7); and
    • R7 represents a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms;
      as well as pharmaceutically acceptable hydrates, solvates and salts thereof.